|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Human Transferrin Receptor / TFRC / CD71 protein (Catalog#11020-H07H)|
|10 μl/Test, 0.1 mg/ml|
|Aqueous solution containing 0.5% BSA and 0.09% sodium azide|
|This antibody was obtained from a rabbit immunized with purified, recombinant Human Transferrin Receptor / TFRC / CD71 (rh Transferrin Receptor / TFRC / CD71; Catalog#11020-H07H; NP_003225.2; Cys89-Phe 760) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.|
|Human Transferrin Receptor / TFRC / CD71|
|This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! |
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Expression of TFRC (CD71) by stimulated human peripheral blood mononuclear cells (PBMC). Human PBMC were stimulated with immobilized anti-human CD3 antibody (1 μg/ml for coating culture wells; BD Cat. No. 555329), in the presence of recombinant human IL-2 (200 IU/ml final concentration) for 3 days.
Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.