Anti-Transferrin Receptor Antibody (FITC)

Cat: 11020-R040-F
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Anti-Transferrin Receptor Antibody (FITC) (Rabbit Monoclonal antibody) General Information
Product name
Anti-Transferrin Receptor Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Transferrin Receptor
Immunogen
Recombinant Human Transferrin Receptor / TFRC / CD71 protein (Catalog#11020-H07H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Transferrin Receptor / TFRC / CD71 (rh Transferrin Receptor / TFRC / CD71; Catalog#11020-H07H; NP_003225.2; Cys89-Phe 760) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Rabbit IgG Clone #040
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-Transferrin Receptor Antibody (FITC) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Transferrin Receptor Antibody (FITC) (Rabbit Monoclonal antibody) Images
Human TFRC/CD71 Flow Cytometry (FC) 5441
Expression of TFRC (CD71) by stimulated human peripheral blood mononuclear cells (PBMC). Human PBMC were stimulated with immobilized anti-human CD3 antibody (1 μg/ml for coating culture wells; BD Cat. No. 555329), in the presence of recombinant human IL-2 (200 IU/ml final concentration) for 3 days.
Anti-Transferrin Receptor Antibody (FITC) Alternative Names
Anti-CD71 Antibody;Anti-p90 Antibody;Anti-T9 Antibody;Anti-TFR Antibody;Anti-TFR1 Antibody;Anti-TR Antibody;Anti-TRFR Antibody
Transferrin Receptor Background Information

Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

Full Name
transferrin receptor
References
  • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
  • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
  • Tosoni D., et al., 2005, Cell 123:875-888.
  • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
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