Transferrin Protein & Antibody

Transferrin Products

Transferrin Protein, Recombinant

Molecule	Species	Description	Cat. No
Transferrin	Human	Transferrin Protein, Recombinant	11019-H08H
Transferrin	Sus scrofa (Pig)	Transferrin Protein, Recombinant	13656-W02H
Transferrin	Sus scrofa (Pig)	Transferrin Protein, Recombinant	13656-W08H

  11019-H08H:  Immobilized human CD71 at 10 µg/ml (100 µl/well) can bind human Transferrin. The EC₅₀ of human Transferrin is 5.6 ng/mL. Measured by its binding ability in a functional ELISA.

Transferrin Antibody

Molecule	Application	Description	Cat. No
Human Transferrin	ELISA, IHC-P	Transferrin / TF Antibody	11019-MM03
Human Transferrin	WB, ELISA	Mouse Monoclonal Antibody	11019-MM06
Human Transferrin	WB, ELISA	Rabbit Polyclonal Antibody	11019-RP01
Human Transferrin	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11019-RP02
Human Transferrin	WB, ELISA	Rabbit Monoclonal Antibody	11019-R101

Transferrin ELISA Kit

Molecule	Application	Description	Cat. No
Human Transferrin	ELISA	Transferrin ELISA Kit	SEK11019

Transferrin cDNA Clone

Molecule	Species	Description	Cat. No
Transferrin	Human	Homo sapiens Transferrin cDNA Clone(NM_001063.2)	HG11019-M

Transferrin Alternative Names

Transferrin, TF, serotransferrin, siderophilin, beta-1 metal-binding globulin, DKFZp781D0156, PRO1557, PRO2086 [Homo sapiens]

Transferrin Background

Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte / pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. Transferrins are iron binding transport proteins which bind Fe3+ ion in association with the binding of an anion, usually bicarbonate. This transferrin binds only one Fe3+ ion per protein molecule. Transports iron ions from the hemolymph into the eggs during the vitellogenic stage. Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. When a transferrin loaded with iron encounters with a transferring receptor on cell surface, transferring binds to it and, as a consequence, is transported into the cell in a visicle by receptor-mediated endocytosis. The PH is reduced by hydrogen iron pumps. The lower pH causes transferrin to release its iron ions. The receptor is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. Each transferrin molecule has the ability to carry two iron ions in the ferric form.

Transferrin Related Studies

1. Ponka P, et al. (1998) Function and regulation of transferrin and ferritin. Semin Hematol. 35(1): 35-54.
2. Wagner E, et al. (1990) Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc Natl Acad Sci. 87(9): 3410-4.
3. Cheng Y, et al. (2004) Structure of the human transferrin receptor-transferrin complex. Cell. 116 (4): 565–76.