Anti-Transferrin Antibody

Cat: 11019-MM06
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Anti-Transferrin Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Transferrin Antibody
Validated applications
ELISA,ELISA(Det)
Species reactivity
Reacts with: Human
Specificity
Human Transferrin
Immunogen
Recombinant Human transferrin protein (Catalog#11019-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Transferrin / TF (rh Transferrin; Catalog#11019-H08H; NP_001054.1; Met 1-Pro 698). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #10A1D11D7
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Transferrin Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
ELISA(Det) 1:1000-1:10000 This antibody will detect Human Transferrin / TF in ELISA pair set (Catalog: # SEK11019). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 11019-MM01).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Transferrin Antibody Alternative Names
Anti-HEL-S-71p Antibody;Anti-PRO1557 Antibody;Anti-PRO2086 Antibody;Anti-TFQTL1 Antibody;Anti-Transferrin Antibody
Transferrin Background Information

Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte / pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. Transferrins are iron binding transport proteins which bind Fe3+ ion in association with the binding of an anion, usually bicarbonate. This transferrin binds only one Fe3+ ion per protein molecule. Transports iron ions from the hemolymph into the eggs during the vitellogenic stage. Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. When a transferrin loaded with iron encounters with a transferring receptor on cell surface, transferring binds to it and, as a consequence, is transported into the cell in a visicle by receptor-mediated endocytosis. The PH is reduced by hydrogen iron pumps. The lower pH causes transferrin to release its iron ions. The receptor is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. Each transferrin molecule has the ability to carry two iron ions in the ferric form.

Full Name
transferrin
References
  • Ponka P, et al. (1998) Function and regulation of transferrin and ferritin. Semin Hematol. 35(1): 35-54.
  • Wagner E, et al. (1990) Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc Natl Acad Sci. 87(9): 3410-4.
  • Cheng Y, et al. (2004) Structure of the human transferrin receptor-transferrin complex. Cell. 116 (4): 565-76.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Transferrin Antibody Mouse Monoclonal ELISA,IHC-P 80586-MM12
    Anti-Transferrin Antibody Rabbit Polyclonal ELISA 80586-T16
    Anti-Transferrin Antibody Rabbit Polyclonal ELISA 80586-RP01
    Anti-Transferrin Antibody Rabbit Monoclonal ELISA,IHC-P 80586-R005
    Anti-Transferrin Antibody Rabbit Polyclonal IHC-P 50817-T08
    Anti-Transferrin Antibody Rabbit Polyclonal ELISA 50817-RP01
    Anti-Transferrin Antibody Rabbit Polyclonal ELISA 11019-RP01
    Anti-Transferrin Antibody Mouse Monoclonal ELISA,IHC-P 11019-MM03
    Anti-Transferrin Antibody Rabbit Monoclonal ELISA 11019-R101
    Anti-Transferrin Antibody Rabbit Polyclonal WB,ELISA,IP 11019-RP02
    Anti-Transferrin Antibody Mouse Monoclonal ELISA(Cap) 11019-MM01
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