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    Coagulation Factor III / Tissue Factor / CD142

    Coagulation Factor III / Tissue Factor / CD142 Protein & Antibody

    Coagulation Factor III / Tissue Factor / CD142N


    This F3 gene encodes coagulation factor III which is a cell surface glycoprotein. Tissue factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, tissue factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

    OMIM-Description for Coagulation Factor III / Tissue Factor / CD142N


    The extrinsic pathway of blood coagulation is initiated by contact of plasma factor VII (F7; 613878) with tissue factor (F3), a cellular membrane glycoprotein that normally is segregated from the bloodstream but can be exposed after tissue injury or newly synthesized in endothelial cells or leukocytes after stimulation by endotoxin and cytokines. Once formed, the tissue factor/factor VII complex converts to a complex of tissue factor and enzymatically active factor VII (F7a); this conversion leads to activation of factors X (F10; 613872) and IX (300746) and prothrombin (176930), and ultimately to formation of fibrin (134570/134580). These processes are regulated by plasma protease inhibitors and by the thrombomodulin (188040)-protein C (612283) pathway. A further regulatory mechanism in the extrinsic pathway is called tissue factor pathway inhibitor (TFPI; 152310). For a review, see Davie et al. (1991). 

    Coagulation Factor III / Tissue Factor / CD142


    Tissue factor, also called platelet tissue factor, factor III, thrombokinase, or CD142 is a protein present in subendothelial tissue, platelets, and leukocytes necessary for the initiation of thrombin formation from the zymogen prothrombin. An incorrect synonym is thromboplastin. In addition to the membrane-bound tissue factor, soluble form of tissue factor was also found which results from alternatively spliced tissue factor mRNA transcripts, in which exon 5 is absent and exon 4 is spliced directly to exon 6.

    Coagulation Factor III / Tissue Factor / CD142 Alternative Names

    Coagulation Factor III / Tissue Factor / CD142 Related Products

    Coagulation Factor III / Tissue Factor / CD142 Proteins

    Product nameProduct name
    Mouse Coagulation Factor III / Tissue Factor / CD142 Protein (His Tag)Rabbit Coagulation Factor III / Tissue Factor / CD142 Protein (ECD, His Tag)Human Coagulation Factor III / Tissue Factor / CD142 Protein (His Tag)Human Coagulation Factor III / Tissue Factor / CD142 Protein (Fc Tag)Rat Coagulation Factor III / Tissue Factor / CD142 Protein (His Tag)

    Coagulation Factor III / Tissue Factor / CD142 Antibodies

    Product nameProduct name
    Coagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit PAbCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit PAb, Antigen Affinity PurifiedCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit MAbCoagulation Factor III / Tissue Factor / CD142 Antibody, Mouse MAbCoagulation Factor III / Tissue Factor / CD142 Antibody (FITC), Mouse MAbCoagulation Factor III / Tissue Factor / CD142 Antibody (PE), Mouse MAb

    Coagulation Factor III / Tissue Factor / CD142 cDNA Clones

    Product nameProduct name
    Human F3 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedHuman F3 Gene cDNA Clone (full-length ORF Clone), expression ready, His-taggedHuman F3 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-taggedHuman F3 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHuman F3 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-taggedRabbit F3 Gene cDNA Clone (full-length ORF Clone) expression ready, Myc-taggedRabbit F3 Gene cDNA Clone (full-length ORF Clone) expression ready, HA-taggedRabbit F3 Gene cDNA Clone (full-length ORF Clone) expression ready, untaggedMouse F3 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedMouse F3 Gene cDNA Clone (full-length ORF Clone), expression ready, His-taggedMouse F3 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-taggedMouse F3 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedMouse F3 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-taggedMouse F3 Gene cDNA Clone (full-length ORF Clone)Rabbit F3 Gene cDNA Clone (full-length ORF Clone)Rabbit F3 Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-taggedHuman F3 Gene cDNA Clone (full-length ORF Clone)Rat F3 Gene cDNA Clone (full-length ORF Clone)Rat F3 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedRat F3 Gene cDNA Clone (full-length ORF Clone), expression ready, His-taggedRat F3 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-taggedRat F3 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedRat F3 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-taggedRabbit F3 Gene cDNA Clone (full-length ORF Clone) expression ready, His-tagged

    Coagulation Factor III / Tissue Factor / CD142 ELISA

    Product nameProduct name
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"