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Coagulation Factor III / Tissue Factor / CD142

Coagulation Factor III / Tissue Factor / CD142 Protein & Antibody

Entrez Gene Summary for Coagulation Factor III / Tissue Factor / CD142


This F3 gene encodes coagulation factor III which is a cell surface glycoprotein. Tissue factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, tissue factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

OMIM-Description for Coagulation Factor III / Tissue Factor / CD142


The extrinsic pathway of blood coagulation is initiated by contact of plasma factor VII (F7; 613878) with tissue factor (F3), a cellular membrane glycoprotein that normally is segregated from the bloodstream but can be exposed after tissue injury or newly synthesized in endothelial cells or leukocytes after stimulation by endotoxin and cytokines. Once formed, the tissue factor/factor VII complex converts to a complex of tissue factor and enzymatically active factor VII (F7a); this conversion leads to activation of factors X (F10; 613872) and IX (300746) and prothrombin (176930), and ultimately to formation of fibrin (134570/134580). These processes are regulated by plasma protease inhibitors and by the thrombomodulin (188040)-protein C (612283) pathway. A further regulatory mechanism in the extrinsic pathway is called tissue factor pathway inhibitor (TFPI; 152310). For a review, see Davie et al. (1991). 

.zh=Coagulation Factor III / Tissue Factor / CD142


Tissue factor, also called platelet tissue factor, factor III, thrombokinase, or CD142 is a protein present in subendothelial tissue, platelets, and leukocytes necessary for the initiation of thrombin formation from the zymogen prothrombin. An incorrect synonym is thromboplastin. In addition to the membrane-bound tissue factor, soluble form of tissue factor was also found which results from alternatively spliced tissue factor mRNA transcripts, in which exon 5 is absent and exon 4 is spliced directly to exon 6.

Coagulation Factor III / Tissue Factor / CD142 Alternative Names

Coagulation Factor III / Tissue Factor / CD142 Related Products

Coagulation Factor III / Tissue Factor / CD142 Proteins

Product nameProduct name
Mouse Coagulation Factor III / Tissue Factor / CD142 Protein (His Tag)Rabbit Coagulation Factor III / Tissue Factor / CD142 Protein (ECD, His Tag)Human Coagulation Factor III / Tissue Factor / CD142 Protein (His Tag)Human Coagulation Factor III / Tissue Factor / CD142 Protein (Fc Tag)Rat Coagulation Factor III / Tissue Factor / CD142 Protein (His Tag)

Coagulation Factor III / Tissue Factor / CD142 Antibodies

Product nameProduct name
Coagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit PAbF3 Antibody (PE), Rabbit MAbCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit MAbCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit PAbCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit PAb, Antigen Affinity PurifiedCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit PAb, Antigen Affinity PurifiedCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit MAbCoagulation Factor III / Tissue Factor / CD142 Antibody, Mouse MAbCoagulation Factor III / Tissue Factor / CD142 Antibody (FITC), Mouse MAbCoagulation Factor III / Tissue Factor / CD142 Antibody (PE), Mouse MAbCoagulation Factor III / Tissue Factor / CD142 Antibody (APC), Mouse MAbCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit PAb, Antigen Affinity PurifiedCoagulation Factor III / Tissue Factor / CD142 Antibody, Rabbit PAb

Coagulation Factor III / Tissue Factor / CD142 cDNA Clones

Product nameProduct name
Rabbit F3 ORF mammalian expression plasmid, N-His tagMouse F3 ORF mammalian expression plasmid, C-HA tagMouse F3 ORF mammalian expression plasmid, C-His tagMouse F3 ORF mammalian expression plasmid, N-Flag tagRat F3 ORF mammalian expression plasmid, N-HA tagRat F3 ORF mammalian expression plasmid, C-OFPSpark / RFP tagMouse F3 ORF mammalian expression plasmid, C-Flag tagRabbit F3 ORF mammalian expression plasmid, N-Flag tagHuman F3 ORF mammalian expression plasmid, N-Myc tagRat F3 ORF mammalian expression plasmid, C-HA tagMouse F3 ORF mammalian expression plasmid, C-Myc tagHuman F3 ORF mammalian expression plasmid, C-OFPSpark / RFP tagRat F3 ORF mammalian expression plasmid, N-His tagRat F3 ORF mammalian expression plasmid, C-His tagHuman F3 ORF mammalian expression plasmid, N-His tagHuman F3 ORF mammalian expression plasmid, C-GFPSpark tagRat F3 ORF mammalian expression plasmid, N-Flag tagRabbit F3 ORF mammalian expression plasmid, C-Flag tagMouse F3 natural ORF mammalian expression plasmidRabbit F3 ORF mammalian expression plasmid, C-Myc tagRat F3 natural ORF mammalian expression plasmidMouse F3 ORF mammalian expression plasmid, C-GFPSpark tagRabbit F3 ORF mammalian expression plasmid, C-GFPSpark tagRabbit F3 ORF mammalian expression plasmid, C-OFPSpark / RFP tagRabbit F3 natural ORF mammalian expression plasmidMouse F3 ORF mammalian expression plasmid, N-Myc tagHuman F3 ORF mammalian expression plasmid, C-Myc tagRat F3 ORF mammalian expression plasmid, C-Myc tagMouse F3 ORF mammalian expression plasmid, C-OFPSpark / RFP tagRat F3 ORF mammalian expression plasmid, C-Flag tagMouse F3 Gene cDNA clone plasmidHuman F3 ORF mammalian expression plasmid, N-HA tagMouse F3 ORF mammalian expression plasmid, N-His tagRabbit F3 Gene cDNA clone plasmidHuman F3 Gene cDNA clone plasmidHuman F3 ORF mammalian expression plasmid, C-HA tagRabbit F3 ORF mammalian expression plasmid, N-Myc tagRat F3 Gene cDNA clone plasmidRabbit F3 ORF mammalian expression plasmid, C-His tagHuman F3 ORF mammalian expression plasmid, C-His tagHuman F3 ORF mammalian expression plasmid, N-Flag tagHuman F3 natural ORF mammalian expression plasmidRabbit F3 ORF mammalian expression plasmid, N-HA tagHuman F3 ORF mammalian expression plasmid, C-Flag tagRat F3 ORF mammalian expression plasmid, C-GFPSpark tagRat F3 ORF mammalian expression plasmid, N-Myc tagMouse F3 ORF mammalian expression plasmid, N-HA tagRabbit F3 ORF mammalian expression plasmid, C-HA tag

Coagulation Factor III / Tissue Factor / CD142 ELISA

Product nameProduct name
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"