TIE2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All TIE2 reagents are produced in house and quality controlled, including 12 TIE2 Antibody, 1 TIE2 ELISA, 39 TIE2 Gene, 10 TIE2 Lysate, 10 TIE2 Protein, 3 TIE2 qPCR. All TIE2 reagents are ready to use.

TIE2 Protein (10)

TIE2 Antibody (12)

TIE2 ELISA Kit & Match Antibody ELISA Pair Set (1)

TIE2 cDNA Clone (39)


TIE2 Lysate (10)

TIE2 Background

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

TIE2 References

  • Jones N, et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-108.
  • Sato A, et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-27.
  • Huang L, et al. (1995) GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK / TIE2 receptor tyrosine kinase. Oncogene. 11(10): 2097-103.