Tie2 / TEK Protein & Antibody

Tyrosine-protein kinase receptor TIE-2

Tie2 Products

Tie2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Tie2	Human	Tie2/Fc Protein, Recombinant	10700-H03H
Tie2	Human	Tie2 Protein, Recombinant	10700-H08H
Tie2	Human	Tie2 / CD202b / TEK Protein, Recombinant, with GST Tag	10700-H20B1
Tie2	Mouse	Tie2 / TEK (aa 770-1122) Protein, Recombinant, with GST Tag	51087-M20B1
Tie2	Mouse	Tie2 / TEK Protein, Recombinant	51087-M08H
Tie2	Rat	Tie2 / CD202b / TEK Protein, Recombinant	80063-R02H

  10700-H03H:  Immobilized recombinant human Angiopoietin-2 at 10µg/ml (100µl/well) can bind Human Tie2/Fc chimera with a range of 0.2- 20µg/ml. Measured by its binding ability in a functional ELISA.

  10700-H08H:  Immobilized recombinant human Tie2 at 2 µg/ml (100µl/well) can bind human Angiopoietin-2 at a linear range of 1.28-160 ng/ml. Measured by its binding ability in a functional ELISA.

Tie2 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Tie2	WB, ELISA	Mouse Monoclonal Antibody	10700-MM01
Human Tie2	WB, ELISA	Rabbit Polyclonal Antibody	10700-RP01
Human Tie2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10700-RP02
Human Tie2	WB, ELISA	TEK / TIE2 / CD202b Antibody	10700-R002
Human Tie2	FCM	Tie2 / CD202b / TEK Antibody ( FITC )	10700-R116-F

Tie2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Tie2	Human	Human Tie2 cDNA Clone / ORF Clone	HG10700-M
Tie2	Mouse	Mouse TEK cDNA Clone / ORF Clone	MG51087-G
Tie2	Rat	Rat Tie2 cDNA Clone / ORF Clone	RG80063-M

Tie2 Alternative Names

TIE2, TIE-2, TEK, CD202B, VMCM, VMCM1 [Homo sapiens]

Tie2, tie-2, Tek, Cd202b, Hyk, RP23-345A23.1, AA517024 [Mus musculus]

Tie2 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>Tie2/CD202b

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>Tie2/CD202b

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>Tie2/CD202b

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>Tie2/CD202b

Cancer>>Growth Factor & Receptor>>Angiopoietin/Tie>>Tie2/CD202b

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>Tie2/CD202b

Immunology>>Cluster of Differentiation>>Other>>Tie2/CD202b

TIE2 / TEK Background

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

TIE2 / TEK Related Studies

1. Jones N, et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-108.
2. Sato A, et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-27.
3. Huang L, et al. (1995) GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK / TIE2 receptor tyrosine kinase. Oncogene. 11(10): 2097-103.