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TEK / Tie2 / CD202b Antibody, Rabbit PAb, Antigen Affinity Purified

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Human Tie2 Antibody Product Information
Immunogen:Recombinant Human TIE2 protein (Catalog#10700-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human TIE2 (rh TIE2; Catalog#10700-H08H; NP_000450.2; Met 1-Lys 745). TIE2 specific IgG was purified by human TIE2 affinity chromatography .
Human Tie2 Antibody Usage Guide
Specificity:Human TEK / TIE2 / CD202b
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human TIE2. The detection limit for Human TIE2 is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other Tie2 Antibody Products
Reactivity: Human  
Application: FCM  
  • Slide 1
10700-MM07-P-100
10700-MM07-P-50
100 Tests 
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Reactivity: Human  
Application: FCM  
  • Slide 1
10700-MM07-F-100
10700-MM07-F-50
100 Tests 
50 Tests 
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Reactivity: Human  
Application: ELISA  
    10700-RP01-100
    10700-RP01-200
    10700-RP01-400
    100 µg 
    200 µg 
     
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    Reactivity: Human  
    Application: ELISA  
      10700-MM01-50
      10700-MM01-100
      10700-MM01-200
      50 µg 
      100 µg 
      200 µg 
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      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10700-R116-F-50
      10700-R116-F-100
      50 Tests 
      100 Tests 
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      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10700-R116-A-100
      10700-R116-A-50
      100 Tests 
      50 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  IF  ICC/IF  
      • Slide 1
      • Slide 1
      10700-R116-100
      10700-R116-50
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  IF  ICC/IF  
      • Slide 1
      • Slide 1
      10700-MM07-200
      10700-MM07-100
      10700-MM07-50
      200 µg 
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10700-MM07-A-100
      10700-MM07-A-50
      100 Tests 
      50 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10700-R116-P-100
      10700-R116-P-50
      100 Tests 
      50 Tests 
      Add to Cart
      Tie2/CD202b/TEK Background

      TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

      Human Tie2/CD202b/TEK References
    • Jones N, et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-108.
    • Sato A, et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-27.
    • Huang L, et al. (1995) GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK / TIE2 receptor tyrosine kinase. Oncogene. 11(10): 2097-103.
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      Catalog: 10700-RP02-50
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      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"