Tie1 Protein

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Tie1 Products

Tie1 Protein, Recombinant

Molecule	Species	Description	Cat. No
Tie1	Human	Tie1 Protein, Recombinant	10509-H08H

Tie1 cDNA Clone

Molecule	Species	Description	Cat. No
Tie1	Human	Homo sapiens Tie1 cDNA Clone	HG10509-M

Tie1 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>Tie1

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>Tie1

Cancer>>Growth Factor & Receptor>>Angiopoietin/Tie>>Tie1

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>Tie1

Tie1 Alternative Names

TIE1, RP11-282K6.6, JTK14, TIE [Homo sapiens]

Tie1, RP23-145E1.8, D430008P04Rik, TIE, tie-1 [Mus musculus]

Tie1 Background

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appears as a 45 kDa truncated receptor fragment. Tie1 promotes endothelial cell survival, but other studies have suggested that the Tie1 kinase has little to no activity. Embryos deficient in Tie1 failed to establish structural integrity of vascular endothelial cells, resulting in oedema and subsequently localized haemorrhage. Tie1 is significantly higher in human aortic endothelial cells than in human umbilical vein endothelial cells. Additionally, attachment of cells of monocytic lineage to endothelial cells is also enhanced by Tie1 expression. Collectively Tie1 has a proinflammatory property and may play a role in the endothelial inflammatory diseases such as atherosclerosis.

Tie1 Related Studies

1. Chan B, et al. (2008) Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochem Biophys Res Commun. 371(3): 475-9.
2. Sato TN, et al. (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 376(6535): 70-4.
3. Rees KA, et al. (2007) The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. Int J Oncol. 31(4): 893-7.
4. Kontos CD, et al. (2002) The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol. 22(6): 1704-13.