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Thrombopoietin/THPO Protein, Antibody, ELISA Kit, cDNA Clone

Thrombopoietin/THPO Related Areas

Thrombopoietin/THPO Related Pathways

Thrombopoietin/THPO Related Product

    Thrombopoietin/THPO Summary & Protein Information

    Thrombopoietin/THPO Related Information

    Thrombopoietin/THPO Background

    Gene Summary: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Alternate splicing results in multiple transcript variants of this gene
    General information above from NCBI
    Domain: Two-domain structure with an erythropoietin-like N- terminal and a Ser/Pro/Thr-rich C-terminal.
    Subcellular location: Secreted.
    Involvement in disease: Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the EPO/TPO family.
    General information above from UniProt

    Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.

    Thrombopoietin/THPO Alternative Name

    Thrombopoietin/THPO Related Studies

  • Ryu T,et al.(2003) Thrombopoietin-producing hepatocellular carcinoma. Intern Med. 42(8): 730-4.
  • Higashihara M,et al. (2003) Thrombopoietin-producing tumor. Intern Med. 42(8): 632-3?
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