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Thrombopoietin/THPO  Protein, Antibody, ELISA Kit, cDNA Clone

Description:   
Expression host: Human Cells  
  • Slide 1
10381-H08H-5
10381-H08H-100
10381-H08H-20
5 µg 
100 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
10381-H08H1-5
10381-H08H1-20
10381-H08H1-100
5 µg 
20 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
10381-H07H-100
10381-H07H-5
10381-H07H-20
100 µg 
5 µg 
20 µg 
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Description: Active  
Expression host: CHO Cells  
  • Slide 1
10381-H08C-100
10381-H08C-5
10381-H08C-20
100 µg 
5 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
10381-H02H-20
10381-H02H-100
20 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
50146-M08H-20
50146-M08H-100
50146-M08H-5
20 µg 
100 µg 
5 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
90004-C08H-20
90004-C08H-100
90004-C08H-5
20 µg 
100 µg 
5 µg 
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Thrombopoietin/THPO Related Pathways

Thrombopoietin/THPO Related Protein, Antibody, cDNA Gene, and ELISA Kits

Thrombopoietin/THPO Related Protein, Antibody, cDNA Gene, and ELISA Kits

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Thrombopoietin/THPO Summary & Protein Information

Thrombopoietin/THPO Related Information

Thrombopoietin/THPO Background

Gene Summary: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Alternate splicing results in multiple transcript variants of this gene
General information above from NCBI
Domain: Two-domain structure with an erythropoietin-like N- terminal and a Ser/Pro/Thr-rich C-terminal.
Subcellular location: Secreted.
Involvement in disease: Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the EPO/TPO family.
General information above from UniProt

Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.

Thrombopoietin/THPO Alternative Name

Thrombopoietin/THPO Related Studies

  • Ryu T,et al.(2003) Thrombopoietin-producing hepatocellular carcinoma. Intern Med. 42(8): 730-4.
  • Higashihara M,et al. (2003) Thrombopoietin-producing tumor. Intern Med. 42(8): 632-3?
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