All Thrombomodulin reagents are produced in house and quality controlled, including 4 Thrombomodulin Antibody, 48 Thrombomodulin Gene, 1 Thrombomodulin Lysate, 1 Thrombomodulin Protein, 3 Thrombomodulin qPCR. All Thrombomodulin reagents are ready to use.
Recombinant Thrombomodulin proteins are expressed by HEK293 Cells with fusion tags as C-His.
Thrombomodulinantibodies are validated with different applications, which are IHC-P, ELISA.
ThrombomodulincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Thrombomodulin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.