All Thioredoxin reagents are produced in house and quality controlled, including 9 Thioredoxin Antibody, 30 Thioredoxin Gene, 2 Thioredoxin IPKit, 2 Thioredoxin Protein, 2 Thioredoxin qPCR. All Thioredoxin reagents are ready to use.
Recombinant Thioredoxin proteins are expressed by E. coli with fusion tags as Native.
Thioredoxinantibodies are validated with different applications, which are ELISA, WB, ICC/IF, IF, IP, IHC-P.
ThioredoxincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Thioredoxin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein which belongs to the thioredoxin family. Thioredoxins are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange. Thioredoxins are found in nearly all known organisms and are essential for life in mammals. Thioredoxin / TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin / TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Thioredoxin / TXN nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Thioredoxin / TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.