Thioredoxin-2 (TXN2)

Thioredoxin-2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 could be involved in the resistance to anti-tumor agents. Thioredoxin-2 possesses a dithiol-reducing activity.

Thioredoxin-2 (TXN2) Related Areas

Enzyme>>Oxidoreductase>>Thioredoxin-2/TXN2

Thioredoxin-2 (TXN2) Alternative Names

Thioredoxin-2, TXN2, RP5-1119A7.13-005, MT-TRX, MTRX, TRX2 [Homo sapiens]

Thioredoxin-2, Txn2, AL583886.2, 2510006J11Rik, AI788873, Trx2 [Mus musculus]

Summaries for Thioredoxin-2 (TXN2)

Entrez Gene summary for Thioredoxin-2 (TXN2):

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

OMIM - description for Thioredoxin-2 (TXN2):

Thioredoxin family proteins, such as TXN2, control cellular redox state and protect against oxidative damage (Chen et al., 2002).

Wikipedia summary for Thioredoxin-2 (TXN2):

Thioredoxin, mitochondrial also known as thioredoxin-2 is a protein that in humans is encoded by the TXN2 gene.

Human Thioredoxin-2 (TXN2) Protein General Information

 

• Protein names: Thioredoxin-2
  Short name=TXN2
• Sequence length: 166 AA.
• Domain: Redox-active center
  Transit peptide
• Sequence similarities: Belongs to the thioredoxin family.
  Contains 1 thioredoxin domain.
• Subunit structure: Monomer.
• Subcellular location: Mitochondrion
• Tissue specificity: Widely expressed in adult (at protein level) and fetal tissues.

General information above from UniProt

Function for Thioredoxin-2 (TXN2) Protein

UniProtKB:

Thioredoxin-2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 could be involved in the resistance to anti-tumor agents. Thioredoxin-2 possesses a dithiol-reducing activity.

Genatlas:

• Thioredoxin-2 may be playing an important role in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis
• Thioredoxin-2 plays a crucial role in regulating the mitochondrial apoptosis signaling pathway
• Thioredoxin-2 plays an important role in regulating cellular apoptosis
• Thioredoxin-2 is attenuated hypoxia-evoked HIF-1alpha accumulation
• Trx2 interacts with specific components of the mitochondrial respiratory chain and plays an important role in the regulation of the mitochondrial membrane potential
• Thioredoxin-2 reduces disulfide bonds and other thiol modifications in all cells using a CXXC motif
• TXN and TXN2 regulate the proliferation and survival of adipose tissue-derived mesenchymal stem cells, and these processes are mediated by the activation of ERK1/2

Homology for human Thioredoxin-2 (TXN2)

• ortholog to murine Txn2
• ortholog to rattus txn2