**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|Anti-Thioredoxin 2 Antibody||Rabbit||Monoclonal||IHC-P,ICC/IF,IF||12557-R054|
|Anti-Thioredoxin 2 Antibody||Rabbit||Monoclonal||ELISA||12557-R056|
|Anti-Thioredoxin 2 Antibody||Rabbit||Polyclonal||ELISA||12557-RP01|
|Anti-Thioredoxin 2 Antibody||Rabbit||Monoclonal||WB,ELISA||12557-R001|