Anti-Thioredoxin 2 Antibody

Cat: 12557-RP02

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Anti-Thioredoxin 2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Thioredoxin 2 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human Thioredoxin 2
Recombinant Human Thioredoxin-2 / TXN2 protein (Catalog#12557-H07E)
Produced in rabbits immunized with purified, recombinant Human Thioredoxin-2 / TXN2 (rh Thioredoxin-2 / TXN2; Catalog#12557-H07E; Q99757; Thr 60-Gly 166). Thioredoxin-2 / TXN2 specific IgG was purified by Human Thioredoxin-2 / TXN2 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Thioredoxin 2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Thioredoxin 2 Antibody (Rabbit Polyclonal antibody) Images
Human Thioredoxin-2/TXN2 Immunohistochemistry(IHC) 3461
Immunochemical staining of human TXN2 in human stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human Thioredoxin-2/TXN2 Immunohistochemistry(IHC) 3463
Immunochemical staining of human TXN2 in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-Thioredoxin 2 Antibody Alternative Names
Anti-MT-TRX Antibody;Anti-MTRX Antibody;Anti-RP5-1119A7. 13-005 Antibody;Anti-TRX2 Antibody
Thioredoxin 2 Background Information

Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.

Full Name
thioredoxin 2
  • Chen Y., et al., 2002, J. Biol. Chem. 277: 33242-8.
  • Smeets A., et al., 2005, Protein Sci. 14: 2610-21.
  • Wen,S. et al., 2009, Am J Med Genet A  149A (2): 155-60.
  • Choudhary C., et al., 2009, Science 325: 834-40.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Thioredoxin 2 Antibody Rabbit Monoclonal IHC-P,ICC/IF,IF 12557-R054
    Anti-Thioredoxin 2 Antibody Rabbit Monoclonal ELISA 12557-R056
    Anti-Thioredoxin 2 Antibody Rabbit Polyclonal ELISA 12557-RP01
    Anti-Thioredoxin 2 Antibody Rabbit Monoclonal WB,ELISA 12557-R001
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