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Thioredoxin-2 / TXN2 Antibody, Rabbit PAb, Antigen Affinity Purified

  • Thioredoxin-2 / TXN2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • Thioredoxin-2 / TXN2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Human TXN2 Antibody Product Information
Immunogen:Recombinant Human Thioredoxin-2 / TXN2 protein (Catalog#12557-H07E)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human Thioredoxin-2 / TXN2 (rh Thioredoxin-2 / TXN2; Catalog#12557-H07E; Q99757; Thr 60-Gly 166). Thioredoxin-2 / TXN2 specific IgG was purified by Human Thioredoxin-2 / TXN2 affinity chromatography.
Human TXN2 Antibody IHC Application Image
Thioredoxin-2 / TXN2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human TXN2 in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Thioredoxin-2 / TXN2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human TXN2 in human stomach with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other TXN2 Antibody Products
Thioredoxin-2/TXN2 Background

Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.

Human Thioredoxin-2/TXN2 References
  • Chen Y., et al., 2002, J. Biol. Chem. 277: 33242-8.
  • Smeets A., et al., 2005, Protein Sci. 14: 2610-21.
  • Wen,S. et al., 2009, Am J Med Genet A  149A (2): 155-60.
  • Choudhary C., et al., 2009, Science 325: 834-40.
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    Catalog: 12557-RP02-50
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"