Anti-Thioredoxin 2 Antibody

Cat: 12557-RP02
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Anti-Thioredoxin 2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Thioredoxin 2 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Thioredoxin 2
Immunogen
Recombinant Human Thioredoxin-2 / TXN2 protein (Catalog#12557-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human Thioredoxin-2 / TXN2 (rh Thioredoxin-2 / TXN2; Catalog#12557-H07E; Q99757; Thr 60-Gly 166). Thioredoxin-2 / TXN2 specific IgG was purified by Human Thioredoxin-2 / TXN2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Thioredoxin 2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Thioredoxin 2 Antibody (Rabbit Polyclonal antibody) Images
Human Thioredoxin-2/TXN2 Immunohistochemistry(IHC) 3461
Immunochemical staining of human TXN2 in human stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human Thioredoxin-2/TXN2 Immunohistochemistry(IHC) 3463
Immunochemical staining of human TXN2 in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-Thioredoxin 2 Antibody Alternative Names
Anti-MT-TRX Antibody;Anti-MTRX Antibody;Anti-RP5-1119A7. 13-005 Antibody;Anti-TRX2 Antibody
Thioredoxin 2 Background Information

Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.

Full Name
thioredoxin 2
References
  • Chen Y., et al., 2002, J. Biol. Chem. 277: 33242-8.
  • Smeets A., et al., 2005, Protein Sci. 14: 2610-21.
  • Wen,S. et al., 2009, Am J Med Genet A  149A (2): 155-60.
  • Choudhary C., et al., 2009, Science 325: 834-40.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Thioredoxin 2 Antibody Rabbit Monoclonal IHC-P,ICC/IF,IF 12557-R054
    Anti-Thioredoxin 2 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,ICC/IF,IF,IP 12557-T62
    Anti-Thioredoxin 2 Antibody Rabbit Monoclonal ELISA 12557-R056
    Anti-Thioredoxin 2 Antibody Rabbit Polyclonal ELISA 12557-RP01
    Anti-Thioredoxin 2 Antibody Rabbit Monoclonal WB,ELISA 12557-R001
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