Tetranectin / CLEC3B Antibody

Tetranectin / CLEC3B Antibody Datasheet

Tetranectin / CLEC3B Antibody Product Information

• Immunogen: Recombinant Human Tetranectin / CLEC3B protein (Catalog#12735-H08H)
• Antibody Type: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
• Clone ID: 05
• Ig Type: Mouse IgG2a
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Tetranectin / CLEC3B (rh Tetranectin / CLEC3B; Catalog#12735-H08H; AAX37102.1; Met 1-Val 202). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Tetranectin / CLEC3B Antibody Usage Guide

• Specificity: Human Tetranectin / CLEC3B
• No cross-reactivity in ELISA with

  Human cell lysate (293 cell line)

• Direct ELISA: 6This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human CLEC3B. The detection limit for Human CLEC3B is approximately 0.039 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Tetranectin / CLEC3B Antibody Background

Tetranectin, also known as C-type lectin domain family 3, member B (CLEC3B), is a homotrimeric plasma and extracellular-matrix protein that binds plasminogen and complex sulphated polysaccharides including heparin. In terms of primary and tertiary structure, Tetranectin is related to the collectin family of Ca (2+)-binding C-type lectins. Tetranectin is encoded in three exons. Exon 3 encodes the carbohydrate recognition domain, which binds to kringle 4 in plasminogen at low levels of Ca (2+). Exon 2 encodes an alpha-helix, which is necessary and sufficient to govern the trimerization of Tetranectin by assembling into a triple-helical coiled-coil structural element. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. TN may play a role in neurological diseases and may serve as a diagnostic aid in multiple sclerosis (MS). The serum or saliva Tetranectin may serve as a potential biomarker for metastatic oral squamous cell carcinoma (OSCC). Decreased plasma Tetranectin or increased Tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis.

References

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