Anti-Tetranectin Antibody

Cat: 12735-RP02
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Anti-Tetranectin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Tetranectin Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Tetranectin
Immunogen
Recombinant Human Tetranectin / CLEC3B protein (Catalog#12735-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Tetranectin / CLEC3B (rh Tetranectin / CLEC3B; Catalog#12735-H08H; AAX37102.1; Met 1-Val 202). Tetranectin / CLEC3B specific IgG was purified by Human Tetranectin / CLEC3B affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Tetranectin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Tetranectin Antibody (Rabbit Polyclonal antibody) Images
Human Tetranectin/CLEC3B Immunohistochemistry(IHC) 4400
Immunochemical staining of human CLEC3B in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-Tetranectin Antibody Alternative Names
Anti-CLEC3B Antibody;Anti-TN Antibody;Anti-TNA Antibody
Tetranectin Background Information

Tetranectin (TN), also known as C-type lectin domain family 3, member B (CLEC3B) is a member of the C-type lectin Family. It is plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes via binding to plasminogen. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. Tetranectin may play a role in the wound healing process. Tetranectin may play a role in neurological diseases and may serve as a diagnostic aid in multiple sclerosis (MS). Tetranectin was found significantly under-expressed in both serum and saliva of metastatic oral squamous cell carcinoma (OSCC) compared to primary OSCC. Tetranectin is thought to enhance proteolytic processes enabling tumor cells to invade and metastasize.

Full Name
C-type lectin domain family 3, member B
References
  • Iba K, et al. (2001) Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity. Mol Cell Biol. 21(22): 7817-25.
  • Stoevring B, et al. (2006) Tetranectin in cerebrospinal fluid of patients with multiple sclerosis. Scand J Clin Lab Invest. 66(7): 577-83.
  • Brunner A, et al. (2007) Expression and prognostic significance of Tetranectin in invasive and non-invasive bladder cancer. Virchows Arch. 450(6): 659-64.
  • Iba K, et al. (2009) Impaired cutaneous wound healing in mice lacking tetranectin. Wound Repair Regen. 17(1): 108-12.
  • Arellano-Garcia ME, et al. (2010) Identification of tetranectin as a potential biomarker for metastatic oral cancer. Int J Mol Sci. 11(9): 3106-21.
  • Wang L, et al. (2010) Tetranectin is a potential biomarker in cerebrospinal fluid and serum of patients with epilepsy. Clin Chim Acta. 411(7-8): 581-3.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Tetranectin Antibody Rabbit Polyclonal ELISA,IHC-P 50700-T24
    Anti-Tetranectin Antibody Rabbit Monoclonal ELISA 50700-R011
    Anti-Tetranectin Antibody Rabbit Polyclonal ELISA 50700-RP01
    Anti-Tetranectin Antibody Rabbit Polyclonal ELISA,IHC-P 50700-RP02
    Anti-Tetranectin Antibody Rabbit Monoclonal ELISA 12735-R008
    Anti-Tetranectin Antibody Rabbit Polyclonal ELISA 12735-RP01
    Anti-Tetranectin Antibody Mouse Monoclonal ELISA(Det) 12735-MM09
    Anti-Tetranectin Antibody Mouse Monoclonal ELISA(Cap) 12735-MM04
    Anti-Tetranectin Antibody Mouse Monoclonal ELISA 12735-MM05
    Anti-Tetranectin Antibody Rabbit Monoclonal IHC-P 12735-R006
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