Testatin

Testatin is a member of the Cystatin family. Cystatins comprise genes that all show expression patterns that are strikingly restricted to reproductive tissue. Cystatins are a family of cysteine protease inhibitors with homology to chicken cystatin. There are typically about 115 amino acids in this family. They are largely acidic, contain four conserved cysteine residues known to form two disulfide bonds, may be glycosylated and/or phosphorylated, with similarity to fetuins, kininogens, stefins, histidine-rich glycoproteins and cystatin-related proteins. Testatin shows homology to family 2 cystatins, a group of broadly expressed small secretory proteins that are inhibitors of cysteine proteases in vitro but whose in vivo functions are unclear. It is expressed in germ cells and somatic cells in reproductive tissues. Testatin is considered a strong candidate for involvement in early testis development. Testatin expression is maintained in the adult Sertoli cell, and it can also be found in a small population of germ cells.

Testatin Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Testatin

Testatin Alternative Names

UNQ1835/PRO3543, FLJ92394, bA218C14.1, cystatin-9-like, testatin [Homo sapiens]

RP23-250M11.7, M12, cresp, testatin, cystatin-9 [Mus musculus]

Summaries for Testatin

Entrez Gene summary for CST9L:

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This CST9L gene is located in the cystatin locus and encodes a protein similar to mouse cystatin 9. Based on its testis-specific expression, it is likely to have a role in tissue reorganization during early testis development. [provided by RefSeq, Jul 2008]

Wikipedia summary for Testatin:

Cystatin-9-like is a protein that in humans is encoded by the CST9L gene.

Human Testatin Protein General Information

 

• Protein names: Cystatin-9-like
• Sequence length: 147 AA.
• Sequence similarities: Testatin belongs to the cystatin family.
• Subcellular location: Secreted

General information above from UniProt

Function for Testatin Protein

Genatlas:

• may be having a role in tissue reorganization during early testis development.