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TXNRD1 Protein, Antibody, ELISA Kit, cDNA Clone

TXNRD1 Related Areas

TXNRD1 Related Pathways

TXNRD1 Related Product

TXNRD1 Summary & Protein Information

TXNRD1 Background

Gene Summary: TXNRD1 gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
General information above from NCBI
Catalytic activity: Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
Cofactor: Binds 1 FAD per subunit.
Subunit structure: Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.
Domain: The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.
Subcellular location: Cytoplasm (By similarity).
Isoform 4: Cytoplasm. Nucleus.
Isoform 5: Cytoplasm.
Tissue specificity: Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
Induction: Isoform 5 is induced by a combination of interferon- beta and retinoic acid (at protein level). Isoform 1 is induced by estradiol or testosterone in HeLa cells.
Post-translational: The N-terminus of isoform 5 is blocked.
ISGylated (Probable).
Sequence similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Contains 1 glutaredoxin domain.
General information above from UniProt

TXNRD1 Alternative Name

TR1,GRIM-12,MGC9145,TR,TRXR1,TXNR,TXNRD1, [human]
TR1,TrxR1,Txnrd1,TR, [mouse]

TXNRD1 Related Studies

  • Gasdaska P.Y., et al., 1995, FEBS Lett. 373:5-9.
  • Rundloef A.-K., et al., 2004, Free Radic. Biol. Med. 36:641-656.
  • Rikova K., et al., 2007, Cell 131:1190-1203.
  • Fritz-Wolf K., et al., 2007, J. Mol. Biol. 370:116-127.
  • Choudhary C., et al., 2009, Science 325:834-840.