TXNL4B (Dim2)

Dim2, also known as TXNL4B, is a member of the DIM1 family. The Dim protein family is composed of two classes, Dim1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. In spite of their biological and structural similarities, Dim1 and Dim2 proteins differ in many aspects. Dim1 bears distinctive structural motifs responsible for its interaction with other spliceosome components. Dim2 forms homodimers and contains specific domains required for its interactions with partners. This originality suggests that although both proteins are involved in pre-mRNA splicing, they are likely to be involved in different biological pathways. Dim2 roduced in E.Coli is a single, non-glycosylated polypeptide chain containing 185 amino acids and having a molecular mass of 21.1kDa. It is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Dim2 has a vital role in pro-mRNA splicing. Dim2 is required in cell cycle progression for S/G2 transition and interacts with PRPF6 subunit of the spliceosome.

TXNL4B (Dim2) Related Areas

Signal Transduction>>Transcription Factor & Regulator>> Dim2 / TXNL4B

TXNL4B (Dim2) Alternative Names

DLP, Dim2 Dim1-like protein, thioredoxin-like protein 4B [Homo sapiens]

DLP, Dim2, thioredoxin-like protein 4B [Mus musculus]

Summaries for TXNL4B (Dim2)

Wikipedia summary for TXNL4B (Dim2):

Thioredoxin-like protein 4B is a protein that in humans is encoded by the TXNL4B gene.

Human TXNL4B (Dim2) Protein General Information

 

• Protein names: Thioredoxin-like protein 4B
  Short name=TXNL4B
• Sequence length: 149 AA.
• Sequence similarities: Belongs to the DIM1 family.
• Subunit structure: Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.
• Subcellular location: Nucleus

General information above from UniProt

Function for TXNL4B (Dim2) Protein

UniProtKB:

TXNL4B plays an essential role in pre-mRNA splicing. TXNL4B is required in cell cycle progression for S/G₂ transition.

Genatlas:

• TXNL4B is implicated in not only cell cycle progression but also in a more specific molecular process such as pre-mRNA splicing
• TXNL4B is involved in pre-mRNA splicing, and participate in different multisubunit complexes and biological processes
• TXNL4B is required for S/G(2) transition