>TXNDC17 (TRP14, TXNL5)
TXNDC17 (TRP14, TXNL5)
Thioredoxin domain-containing protein 17, also known as TXNDC17, TRP14, and TXNL5, is a protein belonging to the thioredoxin superfamily. TXNDC17 is one of the proteins containing thioredoxin domains. Members of this superfamily share similarity of possessing a thioredoxin fold with a consensus active-site sequence (CxxC) and have functions in redox regulation, defense against oxidative stress, regulation of transcription factors, and refolding of disulfide-containing proteins. Thioredoxins are small disulfide-containing redox proteins found in all livings. It serves as a general protein disulfide oxidoreductase.
TXNDC17 (TRP14, TXNL5) Proteins
TXNDC17 (TRP14, TXNL5) Antibodies
TXNDC17 (TRP14, TXNL5) ELISA Pair sets
TXNDC17 (TRP14, TXNL5) cDNA Clones
MGC14353, TRP14, TXNL5[Homo sapiens]
RP23-207N15.4, 4831443O22Rik, D11Ertd672e, TRP14, Txnl5[Mus musculus]
Thioredoxin domain-containing protein 17
Belongs to the thioredoxin family.
The oxidized protein is reduced by TRXR1.
Interacts with TRXR1 and DYNLL1/DNCL1.
Ubiquitously expressed in cell lines.
General information above from UniProt
TXNDC17 is disulfide reductase. TXNDC17 may participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. TXNDC17 modulates TNF-alpha signaling and NF-kappa-B activation. TXNDC17 has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
- TXNDC17 is disulfide reductase modulating TNF-alpha signaling pathways