TSLP Protein

Thymic stromal lymphopoietin

TSLP Products

TSLP Protein, Recombinant

Molecule	Species	Description	Cat. No
TSLP	Mouse	TSLP Protein , Recombinant	51005-M08H

TSLP Related Areas

Immunology>>Adaptive Immunity>>B Cell>>TSLP

TSLP Alternative Names

OTTHUMP00000158998, OTTHUMP00000158999 [Homo sapiens]

thymic stroma-derived lymphopoietin [Mus musculus]

TSLP Background

Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation.  Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4⁺ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.

TSLP Related Studies

1. Comeau MR, et al. (2010) The influence of TSLP on the allergic response. Mucosal Immunol. 3 (2): 138-47.
2. Ziegler SF. (2010) The role of thymic stromal lymphopoietin (TSLP) in allergic disorders. Curr Opin Immunol. 22 (6): 795-9.
3. Liu YJ, et al. (2007) TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation. Annual Review of Immunology. 25: 193-219.
4. He R, et al. (2008) TSLP acts on infiltrating effector T cells to drive allergic skin inflammation.PNAS. 105 (33): 11875-80.