TSC22D1

TSC22 domain family, member 1 (TSC22D1) is one of the TGF-beta-stimulated clone-22 (TSC-22). TSC-22 was reported to be a differentiation-inducing factor which negatively regulates the growth of salivary gland cancer cells. TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors. TSC-22 may play an important role in maintaining the differentiated phenotype in salivary gland tumors, and may be a possible target of leukemia therapy. TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.

TSC22D1 Related Areas

Signal Transduction>>Transcription Factor & Regulator>>TSC22D1

TSC22D1 Alternative Names

TSC22D1, hucep-2, DKFZp686O19206, MGC17597, RP11-269C23.2, TGFB1I4, TSC22 [Homo sapiens]

Tsc22d1, AA589566, AW105905, Egr5, TSC-22, Tgfb1i4, Tsc, Tsc22 [Mus musculus]

Summaries for TSC22D1

Entrez Gene summary for TSC22D1:

TSC22D1 gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of TSC22D1 gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TSC22D1 gene. [provided by RefSeq, Aug 2011]

OMIM - description for TSC22D1:

TSC22D1 encodes a transcription factor and belongs to the large family of early response genes.

Wikipedia summary for TSC22D1:

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.
TSC22 encodes a transcription factor and belongs to the large family of early response genes.
TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.

Human TSC22D1 Protein General Information

 

• Protein names: TSC22 domain family protein 1
  Short name=TSC22D1
• Sequence length: 1073 AA.
• Induction: In aortic endothelial cells, induced by cytokines, including TGFB1.
• Sequence similarities: Belongs to the TSC-22/Dip/Bun family.
• Sequence caution: The sequence BAC02703.1 differs from that shown. Reason: Erroneous initiation.
• Subunit structure: Homodimer or heterodimer. Can form an heterodimer with TSC22D4.
• Subcellular location: Cytoplasm By similarity. Nucleus By similarity.
• Tissue specificity: Widely expressed in fetal and adult tissues.

General information above from UniProt

Function for TSC22D1 Protein

UniProtKB:

TSC22D1 is transcriptional repressor. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter.

Genatlas:

• TSC22D1 is a transcriptional repressor acting on the C-type natriuretic peptide (CNP) promoter
• TSC22D1 regulates cell growth, differentiation and cell death
• TSC22D1 modulates the transcriptional activity of SMAD3 and SMAD4
• TSC22D1 normally contributes to the regulation of hematopoietic precursor cells function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK large granular lymphocyte leukemia
• TSC22D1 is postulated role as an enhancer of CNP transcription, suggesting that TGFbeta-induced upregulation of CNP expression in vascular smooth muscle cells may be mediated in part by increased transcription of TSC22D1

Homology for human TSC22D1

• homolog to murine Tsc22d1 (86.3 pc)
• homolog to chicken TSC22D1 (71.4 pc)