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TSC22D1 Protein, Antibody, ELISA Kit, cDNA Clone

TSC22D1 Related Areas

TSC22D1 Related Pathways

TSC22D1 Related Product

    TSC22D1 Summary & Protein Information

    TSC22D1 Background

    Gene Summary: TSC22D1 gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of TSC22D1 gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TSC22D1 gene. [provided by RefSeq, Aug 2011]
    General information above from NCBI
    Subunit structure: Homodimer or heterodimer. Can form a heterodimer with TSC22D4.
    Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity).
    Tissue specificity: Widely expressed in fetal and adult tissues.
    Induction: In aortic endothelial cells, induced by cytokines, including TGFB1.
    Sequence similarity: Belongs to the TSC-22/Dip/Bun family.
    General information above from UniProt

    TSC22 domain family, member 1 (TSC22D1) is one of the TGF-beta-stimulated clone-22 (TSC-22). TSC-22 was reported to be a differentiation-inducing factor which negatively regulates the growth of salivary gland cancer cells. TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors. TSC-22 may play an important role in maintaining the differentiated phenotype in salivary gland tumors, and may be a possible target of leukemia therapy. TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.

    TSC22D1 Alternative Name

    DKFZp686O19206,hucep-2,MGC17597,RP11-269C23.2,TGFB1I4,TSC22,TSC22D1, [human]
    AW105905,Egr5,Tsc,TSC-22,Tsc22d1,AA589566,Tgfb1i4,Tsc22, [mouse]

    TSC22D1 Related Studies

  • Doi Y, et al. (2008) Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: implications for tumor cell differentiation. Oncol Rep. 19(3): 609-16.
  • Wu X, et al. (2008) The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival. Proc Natl Acad Sci U S A. 105(14): 5414-9.
  • Lu Y, et al. (2007) Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia. 21(11): 2246-57.