TSC22D1 Protein

TSC22 domain family, member 1

TSC22D1 Products

TSC22D1 Protein, Recombinant

Molecule	Species	Description	Cat. No
TSC22D1	Human	TSC22D1 Protein, Recombinant	12724-H07E

TSC22D1 Related Areas

Signal Transduction>>Transcription Factor & Regulator>>TSC22D1

TSC22D1 Alternative Names

TSC22D1, hucep-2, DKFZp686O19206, MGC17597, RP11-269C23.2, TGFB1I4, TSC22 [Homo sapiens]

Tsc22d1, AA589566, AW105905, Egr5, TSC-22, Tgfb1i4, Tsc, Tsc22 [Mus musculus]

TSC22D1 Background

TSC22 domain family, member 1 (TSC22D1) is one of the TGF-beta-stimulated clone-22 (TSC-22). TSC-22 was reported to be a differentiation-inducing factor which negatively regulates the growth of salivary gland cancer cells. TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors. TSC-22 may play an important role in maintaining the differentiated phenotype in salivary gland tumors, and may be a possible target of leukemia therapy. TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.

TSC22D1 Related Studies

1. Doi Y, et al. (2008) Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: implications for tumor cell differentiation. Oncol Rep. 19(3): 609-16.
2. Wu X, et al. (2008) The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival. Proc Natl Acad Sci U S A. 105(14): 5414-9.
3. Lu Y, et al. (2007) Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia. 21(11): 2246-57.