Anti-TROP2 Antibody (FITC)

Cat: 10428-R001-F
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All TROP2 Reagents
Anti-TROP2 Antibody (FITC) (Rabbit Monoclonal antibody) General Information
Product name
Anti-TROP2 Antibody (FITC)
Validated applications
FCM,ICC/IF,IF
Species reactivity
Reacts with: Human
Specificity
Human TROP2
Immunogen
Recombinant Human TROP2 / TACSTD2 protein (Catalog#10428-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human TROP2 / TACSTD2 (rh TROP2 / TACSTD2; Catalog#10428-H08H; NP_002344.2; Met1-Thr274) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Rabbit IgG Clone #001
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-TROP2 Antibody (FITC) (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ICC-IF 10-25 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TROP2 Antibody (FITC) (Rabbit Monoclonal antibody) Images
Human TROP-2/TACSTD2/TACD2 Flow Cytometry (FC) 3
Flow cytometric analysis of anti-Human TROP2 on MCF-7 cells.
Human TROP-2/TACSTD2/TACD2 Immunofluorescence(IF) 2844
Immunofluorescence staining of Human TROP2 in MCF7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Human TROP2 monoclonal antibody (FITC-conjugated, 10 µg/ml) at 37℃ 1 hour. Positive staining was localized to plasma membrane.
Anti-TROP2 Antibody (FITC) Alternative Names
Anti-EGP-1 Antibody;Anti-EGP1 Antibody;Anti-GA733-1 Antibody;Anti-GA7331 Antibody;Anti-GP50 Antibody;Anti-M1S1 Antibody;Anti-TACD2 Antibody;Anti-TROP-2 Antibody;Anti-TROP2 Antibody
TROP2 Background Information

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

Full Name
tumor-associated calcium signal transducer 2
References
  • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
  • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TROP2 Antibody Rabbit Monoclonal ELISA 50922-R064
    Anti-TROP2 Antibody Rabbit Monoclonal ELISA 50922-R065
    Anti-TROP2 Antibody Rabbit Polyclonal ELISA,IHC-P 50922-RP02
    Anti-TROP2 Antibody Rabbit Monoclonal IHC-P 50922-R046
    Anti-TROP2 Antibody (FITC) Mouse Monoclonal FCM,ICC/IF,IF 10428-MM01-F
    Anti-TROP2 Antibody Mouse Monoclonal ELISA(Cap),IHC-P,ICC/IF,IF 10428-MM02
    Anti-TROP2 Antibody (APC) Rabbit Monoclonal FCM 10428-R001-A
    Anti-TROP2 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 10428-RP02
    Anti-TROP2 Antibody (PE) Mouse Monoclonal FCM 10428-MM01-P
    Anti-TROP2 Antibody Rabbit Polyclonal ELISA 10428-RP01
    Anti-TROP2 Antibody Mouse Monoclonal ELISA,ELISA(Det),IHC-P,FCM 10428-MM01
    Anti-TROP2 Antibody Rabbit Monoclonal ELISA,FCM,ICC/IF,IF 10428-R001
    Anti-TROP2 Antibody (PE) Rabbit Monoclonal FCM 10428-R001-P
    Anti-TROP2 Antibody Rabbit Monoclonal WB,ELISA,IHC-P 10428-R030
    Anti-TROP2 Antibody Rabbit Polyclonal ELISA,IHC-P 10428-T24
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