Anti-TROP2 Antibody

Cat: 50922-RP02

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Anti-TROP2 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-TROP2 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse TROP2
Immunogen
Recombinant Mouse TROP-2 / TACSTD2 protein (Catalog#50922-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse TROP-2 / TACSTD2 (rM TROP-2 / TACSTD2; Catalog#50922-M08H; Q8BGV3; Met1-Gln270). TROP-2 / TACSTD2 specific IgG was purified by Mouse TROP-2 / TACSTD2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-TROP2 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TROP2 Antibody (Rabbit Polyclonal antibody) Images

Mouse TROP-2/TACSTD2/TACD2 Immunohistochemistry(IHC) 3173
Immunochemical staining of mouse TACSTD2 in mouse lung with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Mouse TROP-2/TACSTD2/TACD2 Immunohistochemistry(IHC) 3174
Immunochemical staining of mouse TACSTD2 in mouse kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-TROP2 Antibody Alternative Names

Anti-C80403 Antibody;Anti-EGP-1 Antibody;Anti-GA733-1 Antibody;Anti-Ly97 Antibody;Anti-TROP2 Antibody

TROP2 Background Information

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

Full Name
tumor-associated calcium signal transducer 2
References
  • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
  • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TROP2 Antibody Rabbit Monoclonal ELISA 50922-R064
    Anti-TROP2 Antibody Rabbit Monoclonal ELISA 50922-R065
    Anti-TROP2 Antibody Rabbit Monoclonal IHC-P 50922-R046
    Anti-TROP2 Antibody (FITC) Mouse Monoclonal FCM,ICC/IF,IF 10428-MM01-F
    Anti-TROP2 Antibody Mouse Monoclonal ELISA,ELISA(Cap),IHC-P,ICC/IF,IF 10428-MM02
    Anti-TROP2 Antibody (FITC) Rabbit Monoclonal FCM,ICC/IF,IF 10428-R001-F
    Anti-TROP2 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 10428-RP02
    Anti-TROP2 Antibody (APC) Rabbit Monoclonal FCM 10428-R001-A
    Anti-TROP2 Antibody (PE) Mouse Monoclonal FCM 10428-MM01-P
    Anti-TROP2 Antibody Rabbit Polyclonal ELISA 10428-RP01
    Anti-TROP2 Antibody Rabbit Polyclonal ELISA,IHC-P 10428-T24
    Anti-TROP2 Antibody (PE) Rabbit Monoclonal FCM 10428-R001-P
    Anti-TROP2 Antibody Rabbit Monoclonal WB,ELISA,IHC-P 10428-R030
    Anti-TROP2 Antibody Mouse Monoclonal ELISA,ELISA(Det),IHC-P,FCM 10428-MM01
    Anti-TROP2 Antibody Rabbit Monoclonal ELISA,FCM,ICC/IF,IF 10428-R001
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