TROP-2 Protein & Antibody (TACSTD2)

Tumor-Associated Calcium Signal Transducer 2

TROP-2 Products

TROP-2 Protein, Recombinant

Molecule	Species	Description	Cat. No
TROP-2/TACSTD2	Human	TROP2/TACSTD2/Fc Protein, Recombinant	10428-H03H
TROP-2/TACSTD2	Human	TROP2/TACSTD2 Protein, Recombinant	10428-H08H
TROP-2/TACSTD2	Mouse	TROP2 / TACSTD2 Protein, Recombinant	50922-M02H
TROP-2/TACSTD2	Mouse	TROP2 / TACSTD2 Protein, Recombinant	50922-M08H

  10428-H03H:  When cells are added to TROP2 coated plates (10 µg/mL, 100 µL/well), approximately 90%-100% will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells.

TROP-2 Antibody

Molecule	Application	Description	Cat. No
Human TROP-2/TACSTD2	ELISA	Mouse Monoclonal Antibody	10428-MM01
Human TROP-2/TACSTD2	WB	Mouse Monoclonal Antibody	10428-MM02
Human TROP-2/TACSTD2	WB	Mouse Monoclonal Antibody	10428-MM01-F
Human TROP-2/TACSTD2	WB, ELISA	TROP2 / TACSTD2 Antibody	10428-R001
Human TROP-2/TACSTD2	WB, ELISA	TROP-2/TACSTD2 Antibody, Rabbit MAb	10428-R030
Human TROP-2/TACSTD2	WB, ELISA	Rabbit Polyclonal Antibody	10428-RP01
Human TROP-2/TACSTD2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10428-RP02

TROP-2 cDNA Clone

Molecule	Species	Description	Cat. No
TROP-2/TACSTD2	Human	Homo sapiens TROP2/TACSTD2 cDNA Clone(NM_002353.2)	HG10428-M
TROP-2/TACSTD2	Mouse	Mouse TROP2/TACSTD2 cDNA Clone / ORF Clone	MG50922-G

TROP-2 Alternative Names

TROP2, TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, [Homo sapiens]

TROP2, EGP-1, C80403, GA733-1, Ly97, MGC141612, MGC141613 [Mus musculus]

TROP-2 Related Areas

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>TROP-2/TACSTD2

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>TROP-2/TACSTD2

TROP-2 Background

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

TROP-2 Related Studies

1. Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
2. Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.