TRF1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All TRF1 reagents are produced in house and quality controlled, including 4 TRF1 Gene, 1 TRF1 Lysate, 1 TRF1 Protein, 1 TRF1 qPCR. All TRF1 reagents are ready to use.

Recombinant TRF1 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-His.

TRF1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TRF1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

TRF1 Protein (1)

Species

TRF1 Protein, Human, Recombinant (His Tag)

13044-H07B

Expression host: Baculovirus-Insect Cells

Human TERF1/TRF1 Protein 10151
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TRF1 cDNA Clone (4)

Rat
Human
NM_001012464.1
BC029378

TRF1 qPCR Primer (1)

TRF1 Lysate (1)

Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell cycle, acting as an important regulator of mitosis. TRF1 can be bound and modulated by two nucleolar GTP-binding proteins, nucleostemin (NS) and guanine nucleotide binding protein-like 3-like (GNL3L), which exhibit apparently opposite effects on the protein degradation of TRF1. TRF1/TERF1 may has association with cancer. TRF1 may play a significant role in cell differentiation in non-small cell lung cancer (NSCLC). The expression level of TRF1 protein is significantly reduced in kidney cancer and the level is negatively correlated with malignant degree of the cancer. TRF1 expression in malignant gliomas cells, may play a role in the malignant progression of astroglial brain tumors.

Protein
Gene
qPCR
Lysate
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