Anti-TREML2 Antibody

Cat: 11655-RP02
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Anti-TREML2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-TREML2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TREML2
Immunogen
Recombinant Human TREML2 protein (Catalog#11655-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human TREML2 (rh TREML2; Catalog#11655-H08H; NP_079083.2; Met 1-Ser 268). TREML2 specific IgG was purified by human TREML2 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TREML2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TREML2 Antibody Alternative Names
Anti-C6orf76 Antibody;Anti-dJ238O23.1 Antibody;Anti-FLJ13693 Antibody;Anti-MGC149715 Antibody;Anti-MGC149716 Antibody;Anti-TLT-2 Antibody;Anti-TLT2 Antibody;Anti-UNQ6268/PRO20473 Antibody
TREML2 Background Information

Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I  membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There maybe a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8(+) T cell activation.

Full Name
triggering receptor expressed on myeloid cells like 2
References
  • Mungall A.J. et al., 2003, Nature. 425: 805-11.
  • Clark HF. et al., 2003, Genome Res. 13: 2265-70.
  • The MGC Project Team. et al., 2004, Genome Res. 14:2121-7.
  • Hashiguchi M., et al., 2008, Proc. Natl.Acad. Sci. USA.105:10495-500.
  • Leitner,J. et al., 2009, Eur J Immunol. 39 (7):1754-64.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TREML2 Antibody Rabbit Monoclonal ELISA 11655-R001
    Anti-TREML2 Antibody Rabbit Polyclonal ELISA 11655-RP01
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