Anti-TREML2 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human TREML2 protein (Catalog#11655-H08H)
Produced in rabbits immunized with purified, recombinant Human TREML2 (rh TREML2; Catalog#11655-H08H; NP_079083.2; Met 1-Ser 268). Total IgG was purified by Protein A affinity chromatography
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TREML2 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-TREML2 Antibody Alternative Names
Anti-C6orf76 Antibody;Anti-dJ238O23.1 Antibody;Anti-FLJ13693 Antibody;Anti-MGC149715 Antibody;Anti-MGC149716 Antibody;Anti-TLT-2 Antibody;Anti-TLT2 Antibody;Anti-UNQ6268/PRO20473 Antibody
TREML2 Background Information
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There maybe a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8(+) T cell activation.
triggering receptor expressed on myeloid cells like 2
Mungall A.J. et al., 2003, Nature. 425: 805-11. Clark HF. et al., 2003, Genome Res. 13: 2265-70. The MGC Project Team. et al., 2004, Genome Res. 14:2121-7. Hashiguchi M., et al., 2008, Proc. Natl.Acad. Sci. USA.105:10495-500. Leitner,J. et al., 2009, Eur J Immunol. 39 (7):1754-64.