Anti-TLT-1 Antibody (Rabbit Monoclonal antibody) General Information
Reacts with: Human
No cross-reactivity in ELISA with
Recombinant Human TREML1 protein (Catalog#11934-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human TREML1 (rh TREML1; Catalog#11934-H08H; Q86YW5-1; Met1-Pro162).
Monoclonal Rabbit IgG Clone #027
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TLT-1 Antibody (Rabbit Monoclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-TLT-1 Antibody Alternative Names
Anti-dJ238O23.3 Antibody;Anti-GLTL1825 Antibody;Anti-MGC119173 Antibody;Anti-PRO3438 Antibody;Anti-TLT-1 Antibody;Anti-TLT1 Antibody;Anti-UNQ1825/PRO3438 Antibody
TLT-1 Background Information
Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte / macrophages, and dendritic cells, via their association with DAP12. TREML1 / TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1 / TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
triggering receptor expressed on myeloid cells like 1
Washington A.V., et al., 2002, Blood 100:3822-4. Allcock R.J.N., et al., 2003, Eur. J. Immunol. 33:567-77. Washington A.V., et al., 2004, Blood 104:1042-7. Barrow A.D., et al., 2004, J. Immunol. 172:5838-42. Gattis J.L., et al., 2006,J. Biol. Chem. 281:13396-403.