Anti-TREM-2 Antibody

Cat: 11084-RP02

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Anti-TREM-2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-TREM-2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TREM-2
Immunogen
Recombinant Human TREM2 protein (Catalog#11084-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human TREM2 (rh TREM2; Catalog#11084-H08H; NP_061838.1; Met 1-Ser 174). TREM2 specific IgG was purified by human TREM2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TREM-2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TREM-2 Antibody Alternative Names
Anti-TREM-2 Antibody;Anti-Trem2a Antibody;Anti-Trem2b Antibody;Anti-Trem2c Antibody
TREM-2 Background Information

Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.

Full Name
triggering receptor expressed on myeloid cells 2
References
  • Bouchon, A. et al., 2000, J. Immunol. 164: 4991-4995.
  • Paloneva, J. et al., 2002, Am. J. Hum. Genet. 71:656-662. 
  • Prada, I. et al., 2006, Neuroscience. 140 (4): 1139-48.
  • Neumann, H. et al., 2007, J Neuroimmunol. 184 (1-2): 92-9.
  • Thrash, JC. et al., 2009, Neurochem Res. 34 (1): 38-45.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TREM-2 Antibody Rabbit Polyclonal ELISA 50149-T16
    Anti-TREM-2 Antibody Rabbit Monoclonal ELISA 50149-R014
    Anti-TREM-2 Antibody Rabbit Polyclonal ELISA 50149-RP01
    Anti-TREM-2 Antibody Rabbit Monoclonal ELISA(Cap) 11084-R016
    Anti-TREM-2 Antibody Rabbit Polyclonal ELISA 11084-T16
    Anti-TREM-2 Antibody Mouse Monoclonal ELISA(Det) 11084-MM08
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