Quick Order

TREM2 Antibody, Rabbit PAb, Antigen Affinity Purified

    DatasheetReviewsRelated ProductsProtocols
    Human TREM2 Antibody Product Information
    Immunogen:Recombinant Human TREM2 protein (Catalog#11084-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:Produced in rabbits immunized with purified, recombinant Human TREM2 (rh TREM2; Catalog#11084-H08H; NP_061838.1; Met 1-Ser 174). TREM2 specific IgG was purified by human TREM2 affinity chromatography.
    Other TREM2 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      11084-RP01-400
      11084-RP01-200
      11084-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: 
        11084-MM08-50
        11084-MM08-200
        11084-MM08-100
        11084-MM08-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
        Add to Cart
        Reactivity: Human  
        Application: 
          11084-R016-50
          11084-R016-100
          11084-R016-1
          50 µg 
          100 µg 
          1 mg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50149-RP01-400
            50149-RP01-200
            50149-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50149-T16-50
              50149-T16-200
              50149-T16-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              TREM-2/TREM2 Background

              Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.

              Human TREM-2/TREM2 References
            • Bouchon, A. et al., 2000, J. Immunol. 164: 4991-4995.
            • Paloneva, J. et al., 2002, Am. J. Hum. Genet. 71:656-662. 
            • Prada, I. et al., 2006, Neuroscience. 140 (4): 1139-48.
            • Neumann, H. et al., 2007, J Neuroimmunol. 184 (1-2): 92-9.
            • Thrash, JC. et al., 2009, Neurochem Res. 34 (1): 38-45.
            • Product nameProduct name
              Size / Price
              Catalog: 11084-RP02-200
              List Price: 
              Price:      (You Save: )

              Datasheet & Documentation

              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"