Anti-TREM-1 Antibody

Cat: 10511-MM03
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All TREM-1 Reagents
Anti-TREM-1 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-TREM-1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human TREM-1
Recombinant Human TREM1 protein (Catalog#10511-H03H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TREM1 (rh TREM1; Catalog#10511-H03H; NP_061113.1; Met 1-Arg 200). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG2b Clone #6E8G4D4
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TREM-1 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TREM-1 Antibody Alternative Names
Anti-CD354 Antibody;Anti-TREM-1 Antibody
TREM-1 Background Information

TREM1 (triggering receptor expressed on myeloid cells) is a type I  transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growing family of receptors related to NK cell receptors, TREM1 activates downstream signaling events with the help of an adapter protein called DAP12. Expression of TREM1 is up-regulated by bacterial LPS, a ligand for TLR4, as well as lipoteichoic acid. Although its natural ligand has not been identified, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein (MCP)-1. Intracellularly, TREM1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-γ. In an animal model of LPS-induced septic shock, blockade of TREM1 signaling inhibited hyperresponsiveness and death. Thus, it has been demonstrated that TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock.

Full Name
triggering receptor expressed on myeloid cells 1
  • Bouchon, A. et al., 2000, J. Immunol. 164: 4991-4995.
  • Bouchon, A. et al., 2001, Nature. 410: 1103-1107.
  • Bleharski, J.R. et al., 2003, J. Immunol. 170: 3812-3818.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TREM-1 Antibody Rabbit Polyclonal IHC-P,ICC/IF,IF 102376-T10
    Anti-TREM-1 Antibody (PE) Mouse Monoclonal FCM 10511-MM02-P
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    Anti-TREM-1 Antibody Rabbit Polyclonal ELISA,IHC-P 10511-T24
    Anti-TREM-1 Antibody Mouse Monoclonal ELISA(Det) 10511-MM07
    Anti-TREM-1 Antibody Mouse Monoclonal ELISA(Cap) 10511-MM04
    Anti-TREM-1 Antibody Rabbit Polyclonal ELISA 10511-RP01
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