TRAILR4 Protein & Antibody (TNFRSF10D, CD264 Protein)

TNF-Related Apoptosis-Inducing Ligand Receptor 4 (Tumor Necrosis Factor Receptor Superfamily, member 10D; Cluster of Differentiation 264)

TRAIL R4 Products

TRAIL R4 Protein, Recombinant

Molecule	Species	Description	Cat. No
TRAIL R4/TNFRSF10D/CD264	Human	TRAILR4 / TNFRSF10D / DCR2 / CD264 Protein, Recombinant	10413-H03H
TRAIL R4/TNFRSF10D/CD264	Human	TRAILR4 / TNFRSF10D / DCR2 / CD264 Protein, Recombinant	10413-H08H

  10413-H03H:  Immobilized human TNFRSF10D Fc Chimera at 10 µg/ml (100 µl/well) can bind biotinylated TNFSF10 with a linear range of 0.625-20 ng/ml. Measured by its binding ability in a functional ELISA.

  10413-H08H:  Immobilized human TNFRSF10D at 10 µg/ml (100 µl/well) can bind biotinylated TNFSF10 with a linear range of 0.625-40 ng/ml. Measured by its binding ability in a functional ELISA.

TRAIL R4 Antibody

Molecule	Application	Description	Cat. No
Human TRAIL R4/TNFRSF10D/CD264	WB, ELISA	TRAIL R4/TNFRSF10D/CD264 Antibody, Mouse MAb	10413-MM04
Human TRAIL R4/TNFRSF10D/CD264	WB, ELISA	TRAIL R4 / CD264 / TNFRSF10D Antibody	10413-RP01
Human TRAIL R4/TNFRSF10D/CD264	WB, ELISA	TRAIL R4 / CD264 / TNFRSF10D Antibody (Antigen Affinity Purified)	10413-RP02

TRAIL R4 Elisa Pair Set

Molecule	Application	Description	Cat. No
TRAIL R4/TNFRSF10D/CD264	ELISA	TRAIL R4 Elisa Pair Set	SEK10413

TRAIL R4 cDNA Clone

Molecule	Species	Description	Cat. No
TRAIL R4/TNFRSF10D/CD264	Human	TRAILR4 cDNA Clone / ORF Clone	HG10413-M
TRAIL R4/TNFRSF10D/CD264	Cynomolgus	Cynomolgus monkey TNFRSF10D cDNA Clone / ORF Clone	KG90100-G

TRAIL R4 Related Areas

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TRAIL R4/TNFRSF10D/CD264

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>TRAIL R4/TNFRSF10D/CD264

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>>TRAIL R4/TNFRSF10D/CD264

TRAIL R4 Alternative Names

TRAIL R4, CD264, DCR2, TRAILR4, TRUNDD [Homo sapiens]

TRAIL R4, [Mus musculus]

TRAIL R4 Background

Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.

TRAIL R4 Related Studies

1. Degli-Esposti MA, et al. (1997) The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 7(6): 813-20.
2. Meng RD, et al. (2000) The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Mol Ther. 1(2): 130-44.
3. Bouralexis S, et al. (2003) Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. Br J Cancer. 89(1): 206-14.