Quick Order

TRAIL R4 / CD264 / TNFRSF10D Antibody, Rabbit MAb

    DatasheetReviewsRelated ProductsProtocols
    Human TNFRSF10D Antibody Product Information
    Immunogen:Recombinant Human TRAIL R4 / CD264 / TNFRSF10D protein (Catalog#10413-H08H)
    Clone ID:043
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R4 / CD264 / TNFRSF10D (rh TRAIL R4 / CD264 / TNFRSF10D; Catalog#10413-H08H; NP_003831.2; Met1-His211).
    Other TNFRSF10D Antibody Products
    Reactivity: Human  
    Application: 
      10413-MM09-50
      10413-MM09-200
      10413-MM09-100
      10413-MM09-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10413-RP02-50
        10413-RP02-200
        10413-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  IHC-P  
        • Slide 1
        • Slide 1
        10413-MM04-50
        10413-MM04-200
        10413-MM04-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10413-RP01-400
          10413-RP01-200
          10413-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10413-R137-50
            10413-R137-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: 
              10413-MM08-50
              10413-MM08-200
              10413-MM08-100
              10413-MM08-1
              50 µg 
              200 µg 
              100 µg 
              1 mg 
              Add to Cart
              Reactivity: Human  
              Application: IHC-P  
              • Slide 1
              • Slide 1
              10413-R009-50
              10413-R009-100
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Human  
              Application: ELISA  WB  IHC-P  IP  
              • Slide 1
              • Slide 1
              • Slide 1
              • Slide 1
              • Slide 1
              • Slide 1
              10413-T60-50
              10413-T60-200
              10413-T60-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Rhesus  
              Application: ELISA  
                90100-RP01-400
                90100-RP01-200
                90100-RP01-100
                400 µg 
                200 µg 
                100 µg 
                Add to Cart
                Reactivity: Rhesus  
                Application: ELISA  IHC-P  
                • Slide 1
                • Slide 1
                • Slide 1
                90100-T24-50
                90100-T24-200
                90100-T24-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                TRAIL R4/CD264/TNFRSF10D Background

                Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.

                Human TRAIL R4/CD264/TNFRSF10D References
              • Degli-Esposti MA, et al. (1997) The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 7(6): 813-20.
              • Meng RD, et al. (2000) The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Mol Ther. 1(2): 130-44.
              • Bouralexis S, et al. (2003) Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. Br J Cancer. 89(1): 206-14.
              • Product nameProduct name
                Size / Price
                Catalog: 10413-R043-50
                List Price: 
                Price:      (You Save: )
                Size:
                50 µg
                100 µg
                Quantity:+-
                AvailabilityIn Stock
                Add to CartBulk Discount Inquiry

                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"