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TRAIL R2 / TNFRSF10B / CD262 Antibody (PE), Rabbit MAb

  • TRAIL R2 / TNFRSF10B / CD262 Antibody (PE), Rabbit MAb, Flow cytometric
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Human TRAILR2 Antibody Product Information
Immunogen:Recombinant Human TRAIL R2 / TNFRSF10B / CD262 protein (Catalog#10465-H08H)
Clone ID:102
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R2 / TNFRSF10B / CD262 (rh TRAIL R2 / TNFRSF10B / CD262; Catalog#10465-H08H; NP_003833.3; Met 1-Glu 182) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human TRAILR2 Antibody FC Application Image
TRAIL R2 / TNFRSF10B / CD262 Antibody (PE), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Profile of anti-TNFRSF10B (CD262) reactivity on Jurkat cells analyzed by flow cytometry.
Other TRAILR2 Antibody Products
TRAIL R2/CD262/TNFRSF10B Background

Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human TRAIL R2/CD262/TNFRSF10B References
  • Schneider P, et al. (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7(6): 831-6.
  • Ichikawa K, et al. (2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171(2): 1061-9.
  • Walczak H, et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-97.
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    Catalog: 10465-R102-P-25
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    Datasheet & Documentation

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