Anti-DR5 Antibody (PE)

Cat: 10465-R102-P

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Anti-DR5 Antibody (PE) (Rabbit Monoclonal antibody) General Information
Product name
Anti-DR5 Antibody (PE)
Validated applications
Species reactivity
Reacts with: Human
Human DR5
Recombinant Human TRAIL R2 / TNFRSF10B / CD262 protein (Catalog#10465-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R2 / TNFRSF10B / CD262 (rh TRAIL R2 / TNFRSF10B / CD262; Catalog#10465-H08H; NP_003833.3; Met 1-Glu 182) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Monoclonal Rabbit IgG Clone #102
Protein A
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
10 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-DR5 Antibody (PE) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DR5 Antibody (PE) (Rabbit Monoclonal antibody) Images
Human TRAIL R2/CD262/TNFRSF10B Flow Cytometry (FC) 2556
Profile of anti-TNFRSF10B (CD262) reactivity on Jurkat cells analyzed by flow cytometry.
Anti-DR5 Antibody (PE) Alternative Names
Anti-CD262 Antibody;Anti-DR5 Antibody;Anti-KILLER Antibody;Anti-KILLER/DR5 Antibody;Anti-TRAIL-R2 Antibody;Anti-TRAILR2 Antibody;Anti-TRICK2 Antibody;Anti-TRICK2A Antibody;Anti-TRICK2B Antibody;Anti-TRICKB Antibody;Anti-ZTNFR9 Antibody
DR5 Background Information

Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor receptor superfamily, member 10b
  • Schneider P, et al. (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7(6): 831-6.
  • Ichikawa K, et al. (2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171(2): 1061-9.
  • Walczak H, et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-97.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 50412-RP01
    Anti-DR5 Antibody Rabbit Monoclonal ELISA 50412-R131
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 50412-RP02
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 10465-T16
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 10465-RP01
    Anti-DR5 Antibody Rabbit Monoclonal ELISA,FCM 10465-R102
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 10465-RP02
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