Anti-DR5 Antibody

Cat: 50412-R131
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All DR5 Reagents
CRO Services
Product recommended

All DR5 Reagents
Anti-DR5 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-DR5 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse DR5
No cross-reactivity in ELISA with Human TNFRSF10B
Immunogen
Recombinant Mouse TRAIL R2 / TNFRSF10B / CD262 protein (Catalog#50412-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TRAIL R2 / TNFRSF10B / CD262 (rM TRAIL R2 / TNFRSF10B / CD262; Catalog#50412-M08H; NP_064671.2; Met 1-Ser 177).
Source
Monoclonal Rabbit IgG Clone #131
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-DR5 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DR5 Antibody Alternative Names
Anti-DR5 Antibody;Anti-KILLER Antibody;Anti-Ly98 Antibody;Anti-MK Antibody;Anti-TRAILR2 Antibody;Anti-TRICK2A Antibody;Anti-TRICK2B Antibody;Anti-TRICKB Antibody
DR5 Background Information

Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor receptor superfamily, member 10b
References
  • Schneider P, et al. (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7(6): 831-6.
  • Ichikawa K, et al. (2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171(2): 1061-9.
  • Walczak H, et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-97.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 50412-RP01
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 50412-RP02
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 10465-RP01
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 10465-T16
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 10465-T16
    Anti-DR5 Antibody Rabbit Monoclonal ELISA,FCM 10465-R102
    Anti-DR5 Antibody (PE) Rabbit Monoclonal FCM 10465-R102-P
    Anti-DR5 Antibody Rabbit Polyclonal ELISA 10465-RP02
    info info
    添加购物车成功! 添加购物车失败!