TRAIL R2 Protein & Antibody (TNFRSF10B, CD262)

TNF-Related Apoptosis-Inducing Ligand Receptor 2 (Tumor Necrosis Factor Receptor Superfamily, member 10B; Cluster of Differentiation 262)

TRAIL R2 Products

TRAIL R2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TRAIL R2/TNFRSF10B/CD262	Human	TRAIL R2/TNFRSF10B/CD262/Fc Protein, Recombinant	10465-H03H
TRAIL R2/TNFRSF10B/CD262	Human	TRAIL R2/TNFRSF10B/CD262 Protein, Recombinant	10465-H08H
TRAIL R2/TNFRSF10B/CD262	Mouse	TRAIL R2/TNFRSF10B/CD262/Fc Protein, Recombinant	50412-M03H
TRAIL R2/TNFRSF10B/CD262	Mouse	TRAIL R2/TNFRSF10B/CD262 Protein, Recombinant	50412-M08H

10465-H03H: Immobilized human TNFSF10 at 10 µg/ml (100 µl/well) can bind human TNFRSF10B Fc chimera with a linear range of 2.5-40 ng/ml. Measured by its binding ability in a functional ELISA.

10465-H08H: Immobilized human TNFRSF10B at 10 µg/ml (100 µl/well) can bind biotinylated TNFSF10 with a linear range of 0.625-20 ng/ml. Measured by its binding ability in a functional ELISA.

TRAIL R2 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human TRAIL R2/TNFRSF10B/CD262	WB, ELISA	TRAIL R2/TNFRSF10B/CD262 Antibody, Rabbit MAb	10465-R102
Human TRAIL R2/TNFRSF10B/CD262	WB, ELISA	Rabbit Polyclonal Antibody	10465-RP01
Human TRAIL R2/TNFRSF10B/CD262	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10465-RP02
Mouse TRAIL R2/TNFRSF10B/CD262	WB, ELISA	TRAIL R2/TNFRSF10B/CD262 Antibody, Rabbit PAb	50412-RP01
Mouse TRAIL R2/TNFRSF10B/CD262	WB, ELISA	TRAIL R2/TNFRSF10B/CD262 Antibody, Rabbit PAb (Antigen Affinity Purified)	50412-RP02

TRAIL R2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TRAIL R2/TNFRSF10B/CD262	Human	Homo sapiens TRAIL R2/TNFRSF10B/CD262 cDNA Clone(NM_003842.3)	HG10465-M
TRAIL R2/TNFRSF10B/CD262	Mouse	Mus musculus TRAIL R2/TNFRSF10B/CD262 cDNA Clone	MG50412-M

TRAIL R2 Related Areas

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>TRAIL R2/TNFRSF10B/CD262

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TRAIL R2/TNFRSF10B/CD262

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>TRAIL R2/TNFRSF10B/CD262

TRAIL R2 Alternative Names

TRAIL R2, CD262, TNFRSF10B, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 [Homo sapiens]

TRAIL R2, Tnfrsf10b, DR5, KILLER, Ly98, MK, TRAILR2, TRICK2A, TRICK2B, TRICKB [Mus musculus]

TRAIL R2 Background

Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

TRAIL R2 Related Studies

Schneider P, et al. (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7(6): 831-6.
Ichikawa K, et al. (2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171(2): 1061-9.
Walczak H, et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-97.

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