Gene Summary: The protein encoded by this TNFRSF10B gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TRAIL R2 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by TRAIL R2. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this TNFRSF10B gene.General information above from NCBI
Subunit structure: Homotrimer. Can interact with TRADD and RIPK1.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Induction: By ER stress. Regulated by p53/TP53.
Involvement in disease: Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Sequence similarity: Contains 1 death domain.
Contains 3 TNFR-Cys repeats.C
General information above from UniProt