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TRAIL R2/CD262/TNFRSF10B Protein, Antibody, ELISA Kit, cDNA Clone

TRAIL R2/CD262/TNFRSF10B Related Areas

TRAIL R2/CD262/TNFRSF10B Related Pathways

TRAIL R2/CD262/TNFRSF10B Related Product

TRAIL R2/CD262/TNFRSF10B Summary & Protein Information

TRAIL R2/CD262/TNFRSF10B Related Information

TRAIL R2/CD262/TNFRSF10B Background

Gene Summary: The protein encoded by this TNFRSF10B gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TRAIL R2 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by TRAIL R2. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this TNFRSF10B gene.
General information above from NCBI
Subunit structure: Homotrimer. Can interact with TRADD and RIPK1.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Induction: By ER stress. Regulated by p53/TP53.
Involvement in disease: Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Sequence similarity: Contains 1 death domain.
Contains 3 TNFR-Cys repeats.C
General information above from UniProt

Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

TRAIL R2/CD262/TNFRSF10B Alternative Name

TRAIL R2/CD262/TNFRSF10B Related Studies

  • Schneider P, et al. (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7(6): 831-6.
  • Ichikawa K, et al. (2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171(2): 1061-9.
  • Walczak H, et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-97.
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