All DR4 reagents are produced in house and quality controlled, including 10 DR4 Antibody, 1 DR4 ELISA, 15 DR4 Gene, 3 DR4 Lysate, 3 DR4 Protein, 1 DR4 qPCR. All DR4 reagents are ready to use.
Recombinant DR4 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-human IgG1-Fc & His, C-His.
DR4antibodies are validated with different applications, which are FCM, ELISA, ELISA(Det), ELISA(Cap).
DR4cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each DR4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
DR4ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.