TRAIL R1 Protein (TNFRSF10A, CD261 Protein)

TNF-Related Apoptosis-Inducing Ligand Receptor 1 (Tumor Necrosis Factor Receptor Superfamily, member 10B; Cluster of Differentiation 261)

TRAIL R1 Products

TRAIL R1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TRAIL R1/TNFRSF10A/CD261	Human	TRAIL R1/TNFRSF10A/CD261/Fc Protein, Recombinant	10408-H02H
TRAIL R1/TNFRSF10A/CD261	Human	TRAIL R1/TNFRSF10A/CD261/Fc Protein, Recombinant	10408-H03H
TRAIL R1/TNFRSF10A/CD261	Human	TRAIL R1/TNFRSF10A/CD261 Protein, Recombinant	10408-H08H

10408-H03H: Immobilized human TNFSF10 at 10 µg/ml (100 µl/well) can bind human TNFRSF10A Fc Chimera with a linear range of 0.625-20 ng/ml. Measured by its binding ability in a functional ELISA.

TRAIL R1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TRAIL R1/TNFRSF10A/CD261	Human	Homo sapiens TRAIL R1/TNFRSR10A/CD261 cDNA Clone(NM_003844.2)	HG10408-M

TRAIL R1 Related Areas

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>TRAIL R1/TNFRSF10A/CD261

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TRAIL R1/TNFRSF10A/CD261

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>TRAIL R1/TNFRSF10A/CD261

TRAIL R1 Alternative Names

TRAIL R1, TNFRSF10A, CD261, APO2, TRAILR-1, TRAILR1, DR4, MGC9365

TRAIL R1 Background

Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

TRAIL R1 Related Studies

Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.

Product Catalog