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TRAIL R1 / CD261 / TNFRSF10A Antibody, Rabbit PAb, Antigen Affinity Purified

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Human TRAILR1/TNFRSF10A Antibody Product Information
Immunogen:Recombinant Human TRAIL R1 / CD261 / TNFRSF10A protein (Catalog#10408-H08H)
Clone ID:
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human TRAIL R1 / CD261 / TNFRSF10A (rh TRAIL R1 / CD261 / TNFRSF10A; Catalog#10408-H08H; NP_003835.2; Met 1-Asn 239). TRAIL R1 / CD261 / TNFRSF10A specific IgG was purified by Human TRAIL R1 / CD261 / TNFRSF10A affinity chromatography.
Human TRAILR1/TNFRSF10A Antibody Usage Guide
Specificity:Human TRAIL R1 / CD261 / TNFRSF10A

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TNFRSF10A. The detection limit for Human TNFRSF10A is approximately 0.00975 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other TRAILR1/TNFRSF10A Antibody Products
TRAIL R1/CD261/TNFRSF10A Background

Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

Human TRAIL R1/CD261/TNFRSF10A References
  • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
  • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.
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    Catalog: 10408-RP02-200
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