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TRAIL R1 / CD261 / TNFRSF10A Antibody, Rabbit PAb, Antigen Affinity Purified

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    Human TRAILR1/TNFRSF10A Antibody Product Information
    Immunogen:Recombinant Human TRAIL R1 / CD261 / TNFRSF10A protein (Catalog#10408-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:Produced in rabbits immunized with purified, recombinant Human TRAIL R1 / CD261 / TNFRSF10A (rh TRAIL R1 / CD261 / TNFRSF10A; Catalog#10408-H08H; NP_003835.2; Met 1-Asn 239). TRAIL R1 / CD261 / TNFRSF10A specific IgG was purified by Human TRAIL R1 / CD261 / TNFRSF10A affinity chromatography.
    Other TRAILR1/TNFRSF10A Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10408-R101-50
    10408-R101-100
    50 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10408-RP01-400
      10408-RP01-200
      10408-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      Reactivity: Human  
      Application: FCM  
      • Slide 1
      • Slide 1
      10408-MM01-F-25
      10408-MM01-F-100
      25 Test 
      100 Tests 
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      Reactivity: Human  
      Application: ELISA  
        10408-R001-50
        10408-R001-100
        10408-R001-1
        50 µg 
        100 µg 
        1 mg 
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        Reactivity: Human  
        Application: ELISA  
          10408-MM07-50
          10408-MM07-200
          10408-MM07-100
          50 µg 
          200 µg 
          100 µg 
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10408-R101-A-25
          10408-R101-A-100
          25 Test 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10408-MM01-50
          10408-MM01-200
          10408-MM01-100
          10408-MM01-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          • Slide 1
          10408-MM01-P-25
          10408-MM01-P-100
          25 Test 
          100 Tests 
          Add to Cart
          TRAIL R1/CD261/TNFRSF10A Background

          Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

          Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

          Human TRAIL R1/CD261/TNFRSF10A References
        • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
        • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.
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          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"