TRACP / ACP5 Protein

Tartrate-Resistant Acid ATPase/Acid Phosphatase 5, tartrate resistant

TRACP / ACP5 Products

TRACP / ACP5 Protein, Recombinant

Molecule	Species	Description	Cat. No
TRACP/ACP5	Human	TRACP/ACP5 Protein, Recombinant	10550-H08H
TRACP/ACP5	Mouse	TRACP/ACP5 Protein, Recombinant	50274-M08H

  10550-H08H: The specific activity is > 10,000 pmoles / min / µg. Measured by its ability to cleave a substrate, p-Nitrophenyl phosphate (pNPP).

  50274-M08H: The specific activity is > 9,000 pmoles / min / µg. Measured by its ability to cleave a substrate, p-Nitrophenyl phosphate (pNPP).

TRACP / ACP5 cDNA Clone

Molecule	Species	Description	Cat. No
TRACP/ACP5	Human	Homo sapiens TRACP/ACP5 cDNA Clone(NM_001611.3)	HG10550-M
TRACP/ACP5	Mouse	Mus musculus TRACP/ACP5 cDNA Clone	MG50274-M

TRACP/ACP5 Related Areas

Enzyme>>Phosphatase & Regulator>>TRACP/ACP5

Signal Transduction>>Phosphatase & Regulator>>TRACP/ACP5

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Osteoblast & Osteoclast Marker>>TRACP/ACP5

TRACP / ACP5 Alternative Names

TRACP, ACP5, TRAP, MGC117378 [Homo sapiens]

TRACP, Acp5, TRAP [Mus musculus]

TRACP / ACP5 Background

Tartrate-resistant acid phosphatase (TRACP) or acid phosphatase 5, tartrate resistant (ACP5 or TRAP) is a glycosylated monomeric metalloenzyme expressed in mammals. TRACP is associated with osteoblast migration to bone resorption sites, and, once there, TRACP is believed to initiate osteoblast differentiation, activation, and proliferation. TRACP once considered to be just a histochemical marker of osteoclasts is now recognised to be a molecule of widespread occurrence with functions in both the skeleton and the immune system. Two forms of TRACP circulate in human blood, TRACP 5a derived from macrophages and dendritic cells, and TRACP-5b derived from osteoclasts. Recent data have demonstrated the utility of TRACP-5b as a marker of osteoclast number and bone resorption, and serum TRACP-5a as a marker of inflammatory conditions. TRACP is expressed by osteoclasts, macrophages, dendritic cells and a number of other cell types. It has a critical role in many biological processes including skeletal development, collagen synthesis and degradation, the mineralisation of bone, cytokine production by macrophages and dendritic cells, macrophage recruitment, dendritic cell maturation and a role in the development of Th1 responses.

TRACP / ACP5 Related Studies

1. Hayman AR. (2008) Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy. Autoimmunity. 41(3): 218-23.
2. Halleen JM, et al. (2006) Tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption. Clin Lab. 52(9-10): 499-509.
3. Mochizuki Y. (2006) Bone and bone related biochemical examinations. Bone and collagen related metabolites. Tartrate-resistant acid phosphatase (TRACP). Clin Calcium. 16(6): 948-55.
4. Lamp EC, et al. (2000) Biology of tartrate-resistant acid phosphatase. Leuk Lymphoma. 39(5-6): 477-84.