TPST1

TPST1 catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

TPST1 Related Areas

Enzyme>>Carbohydrate Metabolism Enzymes>>TPST1/TPST-1

Enzyme>>Sulfatase & Sulfotransferase>>TPST1/TPST-1

TPST1 Alternative Names

TPST1, TPST-1 [Homo sapiens]

Tpst1, TPST-1, R75054 [Mus musculus]

Summaries for TPST1

Wikipedia summary for TPST1:

Tyrosylprotein sulfotransferase is an enzyme that catalyzes tyrosine sulfation.

Human TPST1 Protein General Information

 

• Protein names: Tyrosylprotein sulfotransferase 1
  Short name=TPST1
• Sequence length: 370 AA.
• Domain: Signal-anchor
  Transmembrane
  Transmembrane helix
• Sequence similarities: Belongs to the protein sulfotransferase family.
• Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein.
• Catalytic activity: 3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.

General information above from UniProt

Function for TPST1 Protein

UniProtKB:

TPST1 catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

Genatlas:

• TPST1 catalyzes tyrosine o-sulfation of proteins
• TPST1 acts in targeting and retention of the enzyme to the trans-Golgi compartment
• TPST1 transfers the sulfate moiety to proteins predominantly designated for secretion
• TPST1 may be functional as homodimer/oligomer in the trans-Golgi compartment
• TPST1 is involved in photoreceptor outer segment morphogenesis, retinal function and retinal anatomy
• Tyrosine O-sulfation is a post-translational modification catalyzed by two tyrosylprotein sulfotransferases (TPST1 and TPST2) in the trans-Golgi network