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>TPP1 / CLN2 Protein
TPP1 / CLN2 Protein
Tripeptidyl peptidase I Protein
TPP1 / CLN2 Products
TPP1 / CLN2 Protein, Recombinant
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|TPP1 / CLN2||Human||TPP1 / CLN2 Protein, Recombinant with His Tag||13507-H08B|
TPP1 / CLN2 Related Areas
TPP1 / CLN2 Alternative Names
GIG1, CLN2, LPIC, TPP-1, cell growth-inhibiting gene 1 protein, growth-inhibiting protein 1, lysosomal pepstatin insensitive protease, tripeptidyl aminopeptidase, tripeptidyl-peptidase 1[Homo sapiens]
Cln2, TPP-I, LPIC, TPP-1, ceroid-lipofuscinosis, neuronal 2, lysosomal pepstatin-insensitive protease, tripeptidyl aminopeptidase, tripeptidyl peptidase-I, tripeptidyl-peptidase 1[Mus musculus]
TPP1 / CLN2 Background
Tripeptidyl-peptidase 1 (TPP1 / CLN2) is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. TPP1 / CLN2 May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Defects in TPP1 / CLN2 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2), a form of neuronal ceroid lipofuscinosis which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
TPP1 / CLN2 Related Studies
- Xin H, et al. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature. 445(7127): 559-62.
- O'Connor MS, et al. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci U S A. 103(32): 11874-9.
- Abreu E, et al. (2010) TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol. 30(12): 2971-82.