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TPM1 / Tropomyosin-1 Protein, Antibody, ELISA Kit, cDNA Clone

TPM1 / Tropomyosin-1 Related Areas

TPM1 / Tropomyosin-1 Related Pathways

TPM1 / Tropomyosin-1 Related Product

    TPM1 / Tropomyosin-1 Summary & Protein Information

    TPM1 / Tropomyosin-1 Background

    Subunit structure: Heterodimer of an alpha and a beta chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (By similarity).
    Domain: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven- residues periodicity.
    Subcellular location: Cytoplasm, cytoskeleton.
    Tissue specificity: Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.
    Post-translational: Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.
    Involvement in disease: Cardiomyopathy, familial hypertrophic 3 (CMH3) [MIM:115196]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Cardiomyopathy, dilated 1Y (CMD1Y) [MIM:611878]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the tropomyosin family.
    General information above from UniProt

    TPM1, also known as tropomyosin-1, is a member of the tropomyosin family. Members of this family are highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM1 is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle. It binds to actin filaments in muscle and non-muscle cells. TPM1 plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.

    TPM1 / Tropomyosin-1 Alternative Name

    tropomyosin 1 (alpha),TPM1,C15orf13,CMD1Y,CMH3,HTM-alpha,TMSA,alpha-tropomyosin,cardiomyopathy,hypertrophic 3,sarcomeric tropomyosin kappa,tropomyosin 1 (alpha) isoform 1,tropomyosin 1 (alpha) isoform 2,tropomyosin 1 (alpha) isoform 3,tropomyosin 1 (alpha) isoform 4,tropomyosin 1 (alpha) isoform 5,tropomyosin 1 (alpha) isoform 6,tropomyosin 1 (alpha) isoform 7,tropomyosin alpha-1 chain, [human]
    tropomyosin 1, alpha,Tpm1,AA986836,AI854628,TM2,Tm3,Tmpa,Tpm-1,alpha-TM,alpha tropomyosin,tropomyosin alpha-1 chain,tropomyosin-1, [mouse]

    TPM1 / Tropomyosin-1 Related Studies

  • Mogensen J. et al., 1999, Cytogenet Cell Genet. 84 (1-2): 35-6.
  • Brown H R. et al., 1985, Proc Natl Acad Sci. 82 (8): 2359-63.
  • Lees-Miller JP. et al., 1992, BioEssays. 13 (9): 429-37.
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