All APRIL reagents are produced in house and quality controlled, including 1 APRIL Antibody, 39 APRIL Gene, 1 APRIL Lysate, 1 APRIL Protein, 2 APRIL qPCR. All APRIL reagents are ready to use.
Recombinant APRIL proteins are expressed by HEK293 Cells with fusion tags as N-human IgG1-Fc.
APRILantibodies are validated with different applications, which are WB, IHC-P.
APRILcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each APRIL of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. It is a ligand for TNFRSF17/BCMA. TNFSF13 is lowly expressed in normal tissues, but is elevated in several types of tumors and transformed cell lines. It is mportant for B cell development. TNFSF13 may also play a role in T-independent type II antigen responses and T cell survival, and induce proliferation/survival of non lymphoid cells. It exists as a functional homotrimer. It can bind to two cell surface receptors, BCMA and TACI, which it shares with BAFF to exert downstream T- and B-cell regulatory effects. TNFSF13 also has been demonstrated to bind to proteoglycans on the cell surface.