All TWEAK reagents are produced in house and quality controlled, including 60 TWEAK Gene, 4 TWEAK Lysate, 4 TWEAK Protein, 3 TWEAK qPCR. All TWEAK reagents are ready to use.
Recombinant TWEAK proteins are expressed by HEK293 Cells with fusion tags as N-human IgG1-Fc, N-rabbit IgG-Fc, N-mouse IgG1-Fc.
TWEAKcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TWEAK of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.