TNFRSF25 / DR3 Protein (TNFRSF12 Protein)

Tumor Necrosis Factor Receptor Superfamily, member 25 / Death Receptor 3 (Tumor Necrosis Factor Receptor Superfamily, member 25)

TNFRSF25 / DR3 Products

TNFRSF25 / DR3 Protein, Recombinant

Molecule	Species	Description	Cat. No
TNFRSF25/DR3/TNFRSF12	Human	TNFRSF25/DD3/TNFSF12 Protein, Recombinant	12095-H02H

TNFRSF25 / DR3 cDNA Clone

Molecule	Species	Description	Cat. No
TNFRSF25/DR3/TNFRSF12	Human	Homo sapiens TNFRSF25/DD3/TNFSF12 cDNA Clone	HG12095-G

TNFRSF25 / DR3 Related Areas

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNFRSF25/DR3/TNFRSF12

TNFRSF25 / DR3 Alternative Names

TNFRSF25, DR3, TNFRSF12, RP4-650H14.2, APO-3, DDR3, LARD, TR3, TRAMP, WSL-1, WSL-LR [Homo sapiens]

Tnfrsf25, DR3, Tnfrsf12, RP23-284C20.2, APO-3, DDR3, LARD, TR3, TRAMP, WSL-1, WSL-LR, Wsl [Mus musculus]

TNFRSF25 / DR3 Background

Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this TNFRSF25 encoding gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

TNFRSF25 / DR3 Related Studies

1. Slebioda TJ, et al. (2011) Triggering of TNFRSF25 promotes CD8⁺ T-cell responses and anti-tumor immunity. Eur J Immunol. 41(9): 606-11.
2. Fang L, et al. (2008) Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J Exp Med. 205(5): 037-48.
3. Borysenko CW, et al. (2005) Comparative modeling of TNFRSF25 (DR3) predicts receptor destabilization by a mutation linked to rheumatoid arthritis. Biochem Biophys Res Commun. 328(3): 94-9.