DR6 cDNA ORF Clone in Cloning Vector, Human

Cat: HG12171-G
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All DR6 Reagents
CRO Services
Product recommended

All DR6 Reagents
DR6 cDNA ORF Clone in Cloning Vector, Human General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1419 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human tumor necrosis factor receptor superfamily, member.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
DR6 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

DR6 cDNA ORF Clone in Cloning Vector, Human Alternative Names
BM-018 cDNA ORF Clone, Human;CD358 cDNA ORF Clone, Human;DR6 cDNA ORF Clone, Human
DR6 Background Information

TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

Full Name
tumor necrosis factor receptor superfamily, member 21
References
  • Pan G, et al. (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431(3): 351-6.
  • Benschop R, et al. (2009) Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol. 647: 186-94.
  • Klma M, et al. (2009) Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta. 1793(10): 1579-87.
  • DR6 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    DR6 cDNA ORF Clone in Cloning Vector, Rat RG80155-G
    DR6 cDNA ORF Clone, Rat, untagged RG80155-UT
    DR6 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80155-ACG
    DR6 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80155-ACGLN
    DR6 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80155-ACR
    DR6 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80155-CF
    DR6 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80155-NF
    DR6 cDNA ORF Clone, Rat, C-His tag RG80155-CH
    DR6 cDNA ORF Clone, Rat, N-His tag RG80155-NH
    DR6 cDNA ORF Clone, Rat, C-HA tag RG80155-CY
    DR6 cDNA ORF Clone, Rat, N-HA tag RG80155-NY
    DR6 cDNA ORF Clone, Rat, C-Myc tag RG80155-CM
    DR6 cDNA ORF Clone, Rat, N-Myc tag RG80155-NM
    DR6 qPCR Primer Pairs, Rat RP300150

    DR6 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    DR6 cDNA ORF Clone in Cloning Vector, Mouse MG50263-G
    DR6 cDNA ORF Clone, Mouse, untagged MG50263-UT
    DR6 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50263-ACGLN
    DR6 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50263-ACG
    DR6 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50263-ACR
    DR6 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50263-CF
    DR6 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50263-NF
    DR6 cDNA ORF Clone, Mouse, C-His tag MG50263-CH
    DR6 cDNA ORF Clone, Mouse, N-His tag MG50263-NH
    DR6 cDNA ORF Clone, Mouse, C-HA tag MG50263-CY
    DR6 cDNA ORF Clone, Mouse, N-HA tag MG50263-NY
    DR6 cDNA ORF Clone, Mouse, C-Myc tag MG50263-CM
    DR6 cDNA ORF Clone, Mouse, N-Myc tag MG50263-NM
    DR6 qPCR Primer Pairs, Mouse MP200288

    DR6 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    DR6 cDNA ORF Clone in Cloning Vector, Human HG10175-M
    DR6 cDNA ORF Clone, Human, untagged HG10175-UT
    DR6 cDNA ORF Clone, Human, untagged HG12171-UT
    DR6 cDNA ORF Clone, Human, C-GFPSpark® tag HG10175-ACG
    DR6 cDNA ORF Clone, Human, C-GFPSpark® tag HG12171-ACG
    DR6 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10175-ACGLN
    DR6 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG12171-ACGLN
    DR6 cDNA ORF Clone, Human, C-OFPSpark® tag HG12171-ACR
    DR6 cDNA ORF Clone, Human, C-OFPSpark® tag HG10175-ACR
    DR6 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG12171-CF
    DR6 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10175-CF
    DR6 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG12171-NF
    DR6 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10175-NF
    DR6 cDNA ORF Clone, Human, C-His tag HG10175-CH
    DR6 cDNA ORF Clone, Human, C-His tag HG12171-CH
    DR6 cDNA ORF Clone, Human, N-His tag HG12171-NH
    DR6 cDNA ORF Clone, Human, N-His tag HG10175-NH
    DR6 cDNA ORF Clone, Human, C-HA tag HG12171-CY
    DR6 cDNA ORF Clone, Human, C-HA tag HG10175-CY
    DR6 cDNA ORF Clone, Human, N-HA tag HG10175-NY
    DR6 cDNA ORF Clone, Human, N-HA tag HG12171-NY
    DR6 cDNA ORF Clone, Human, C-Myc tag HG12171-CM
    DR6 cDNA ORF Clone, Human, C-Myc tag HG10175-CM
    DR6 cDNA ORF Clone, Human, N-Myc tag HG12171-NM
    DR6 cDNA ORF Clone, Human, N-Myc tag HG10175-NM
    DR6 qPCR Primer Pairs, Human HP100243
    info info
    添加购物车成功! 添加购物车失败!