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> TNFRSF21 / DR6 Protein & Antibody TNFRSF21 / DR6 Protein & Antibody
Tumor Necrosis Factor Receptor Superfamily, member 21 / Death Receptor 6
TNFRSF21 / DR6 Products
TNFRSF21 / DR6 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| TNFRSF21/DR6 | Human | TNFRSF21/DR6/Fc Protein, Recombinant | 10175-H02H |
| TNFRSF21/DR6 | Human | TNFRSF21/DR6 Protein, Recombinant | 10175-H08H |
| TNFRSF21/DR6 | Human | TNFRSF21/DR6 Protein, Recombinant | 10175-HCCH |
| TNFRSF21/DR6 | Mouse | TNFRSF21/DR6 Protein, Recombinant | 50263-M08H |
TNFRSF21 / DR6 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human TNFRSF21/DR6 |
WB, ELISA | TNFRSF21/DR6 Antibody, Rabbit MAb | 10175-R001 |
| Mouse TNFRSF21/DR6 |
WB, ELISA | TNFRSF21/DR6 Antibody, Rabbit PAb | 50263-RP01 |
| Mouse TNFRSF21/DR6 |
WB, ELISA | TNFRSF21/DR6 Antibody, Rabbit PAb (Antigen Affinity Purified) | 50263-RP02 |
TNFRSF21 / DR6 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| TNFRSF21/DR6 | Human | Homo sapiens TNFRSF21/DR6 cDNA Clone(NM_014452.3) | HG10175-M |
| TNFRSF21/DR6 | Human | TNFRSF21 cDNA Clone / ORF Clone | HG12171-G |
| TNFRSF21/DR6 | Mouse | Mus musculus TNFRSF21/DR6 cDNA Clone | MG50263-M |
| TNFRSF21/DR6 | Rat | Rat TNFRSF21/DR6 cDNA Clone | RG80155-G |
TNFRSF21 / DR6 Related Areas
Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNFRSF21/DR6
TNFRSF21 / DR6 Alternative Names
TNFRSF21, DR6, BM-018, MGC31965 [Homo sapiens]
Tnfrsf21, DR6, AA959878, R74815, TR7 [Mus musculus]
TNFRSF21 / DR6 Related Products
Protein Products
Antibody Products
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! |
| Human TNFRSF1B/TNFR2/CD120b |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human TNFRSF1B/TNFR2/CD120b |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human TNFRSF5/CD40 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human TNFRSF5/CD40 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human TNFRSF10B/CD262/ TRAILR2 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human TNFRSF10B/CD262/ TRAILR2 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
cDNA Clone Products
TNFRSF21 / DR6 Background
TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.
TNFRSF21 / DR6 Related Studies
- Pan G, et al. (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431(3): 351-6.
- Benschop R, et al. (2009) Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol. 647: 186-94.
- Klíma M, et al. (2009) Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta. 1793(10): 1579-87.
