Anti-DR6 Antibody

Cat: 10175-R001
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All DR6 Reagents
Anti-DR6 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-DR6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human DR6
Immunogen
Recombinant Human DR6 protein (Catalog#10175-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF21 (rh TNFRSF21; Catalog#10175-H08H; Met 1-Leu 350; NP_055267.1) .
Source
Monoclonal Rabbit IgG Clone #001
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-DR6 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DR6 Antibody Alternative Names
Anti-BM-018 Antibody;Anti-CD358 Antibody;Anti-DR6 Antibody
DR6 Background Information

TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

Full Name
tumor necrosis factor receptor superfamily, member 21
References
  • Pan G, et al. (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431(3): 351-6.
  • Benschop R, et al. (2009) Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol. 647: 186-94.
  • Klma M, et al. (2009) Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta. 1793(10): 1579-87.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DR6 Antibody Rabbit Polyclonal ELISA 50263-RP01
    Anti-DR6 Antibody Rabbit Polyclonal ELISA 50263-RP02
    Anti-DR6 Antibody Rabbit Polyclonal ELISA 50263-T16
    Anti-DR6 Antibody Rabbit Polyclonal ELISA 10175-RP01
    Anti-DR6 Antibody Rabbit Polyclonal WB,ELISA 10175-T48
    Anti-DR6 Antibody Mouse Monoclonal ELISA 10175-MM03
    info info
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