|Datasheet||Specific References||Reviews||Related Products||Protocols|
|ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) tumor necrosis factor receptor superfamily, member 1B DNA.|
|Identical with XM_001102483.2 [ Macaca mulatta (Rhesus monkey) ]: 1217 C/T resulting in the amino acid Thr substitution by Met and 609 A/G，933 A/G，1284 G/A，1287 C/T not causing the amino acid variation. Please check the sequence information before order.|
|Whatman FTA elute card (Cat: WB120410) contains 5-10 μg of plasmid.|
|The Whatman FTA elute card can be stored at room temperature for three months under dry condition.|
The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.
The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.
|Cynomolgus monkey TNFRSF1B Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged||CG90102-G-F|
|Cynomolgus monkey TNFRSF1B Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged||CG90102-G-H|
|Cynomolgus monkey TNFRSF1B Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-tagged||CG90102-G-M|
|Cynomolgus monkey TNFRSF1B Gene cDNA Clone (full-length ORF Clone), expression ready, untagged||CG90102-G-N|
|Cynomolgus monkey TNFRSF1B Gene cDNA Clone (full-length ORF Clone), expression ready, HA-tagged||CG90102-G-Y|
|Product name||Product name|
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.